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Record W4412001698 · doi:10.1016/j.identj.2025.03.024

Unilateral Agenesis of the Upper Permanent Lateral Incisors in Growing Patients: Gap Closure or Gap Opening? A Systematic Review

2025· review· en· W4412001698 on OpenAlexaboutno aff
Gianna Dipalma, Angelo Michele Inchingolo, Pietro Lauria, Pierluigi Marotti, Silvia Chieppa, Daniela Di Venere, Andrea Palermo, Massimo Corsalini, Francesco Inchingolo, Alessio Danilo Inchingolo

Bibliographic record

VenueInternational Dental Journal · 2025
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
Topicdental development and anomalies
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineGingival recessionDentistryMEDLINEAgenesisProspective cohort studyOrthodonticsSurgery

Abstract

fetched live from OpenAlex

INTRODUCTION: The optimal treatment for agenesis of maxillary lateral incisors is difficult to determine. The objective of this study was to determine, based on the evidence in the literature, the best treatment option for unilateral agenesis of upper lateral incisors, comparing the aesthetic and periodontal results of orthodontic closure of the space associated with canine camouflage versus the opening of the space and the subsequent placement of an implant, in the permanent dentition of growing patients. MATERIALS AND METHODS: Electronic databases (Scopus, PubMed, and Medline) were examined with the subsequent filters: English language; year of publication since 2012; humans. A manual screening of the reference lists of the potential studies was done. Risk of bias was measured by the Newcastle-Ottawa Scale. RESULTS: The search found 379 publications, but 167 of them were duplicates, therefore, they were excluded. Titles and abstracts of 170 articles were accessed, and 128 were excluded. After applying the inclusion and exclusion criteria, 42 articles were fully reviewed, and 7 studies were included. Data were collected from the chosen articles and organized into a table for comparison and study of the results. In contrast to patients treated with implant, whose major disadvantage is infraocclusion, patients who received space closure and canine camouflage had better aesthetic and periodontal outcomes. CONCLUSION: Even if the best treatment option depends on the type of malocclusion of the patient, if both treatment alternatives are available, space closure is the better solution. However, because research samples are small and post-treatment evaluations are short, more prospective cohort studies are needed in the future to give better scientific evidence.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.088
Threshold uncertainty score0.791

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.305
Teacher spread0.288 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes1
Has abstractyes

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