Hydrazone-crosslinked poly(oligoethylene glycol methacrylate)-based hydrogels with physically entrapped phage effectively control Pseudomonas aeruginosa infections in a burn wound model
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
First-line treatments for treating wound infections are under threat from the increase in antimicrobial resistant bacteria, a threat further exacerbated in burn wounds in which the immune response to the infection site is blocked by burned skin. Herein, we report a tuneable and in situ-gelling poly(oligoethylene glycol methacrylate) bulk hydrogel containing bacteriophage (phage), viruses that allow for highly efficient and specific killing of bacteria without the need for conventional antibiotics. The resulting phage-hydrogel has suitable mechanical strength (1.5 kPa compressive modulus) and stability (up to 5 days when fully hydrated) for use as a burn wound dressing while also maintaining excellent antibiotic properties (>4-log reduction of Pseudomonas aeruginosa in a murine in vivo infection burn wound model). Coupled with the beneficial hydrating properties of hydrogels for promoting burn wound healing, the phage-hydrogel dressing offers potential for managing complex burn wound infections.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it