Comparison of Antibody Status Following COVID-19 Vaccination between SARS-Cov-2 Infected and Non-infected Healthcare Professionals of Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh
Bibliographic record
Abstract
BACKGROUND Antibody developed through COVID-19 vaccination plays a vital role in combating further infection and suppressing pathogenesis of SARS-CoV-2. This study aims to observe the difference in antibody status between COVID-19 infected and non-infected healthcare professionals following two doses of COVID-19 vaccine. METHODS This cross-sectional, analytical study was conducted in the Department of Biochemistry and Molecular Biology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, between March 2021 and February 2022. A total of 70 adult participants (healthcare professionals) were included in this study from different departments of BSMMU Hospital. Study participants were categorized into two groups; each group had 35 participants. Group A includes healthcare professionals who were infected by SARS CoV-2 and later vaccinated by two doses of AstraZeneca COVID-19 vaccine, while Group B consists of those who were not infected by SARS CoV-2 but took two doses of AstraZeneca COVID-19 vaccine. We collected participants’ demographic profile and detailed history including co-morbidities and related test results in the data collection sheet. Serum IgG was assessed by chemiluminescent microparticle immunoassay method. RESULTS Serum IgG levels were found in group A as a median 2183.2 AU/ml with an IQR (inter quartile range) of 3852.0 AU/ml, while in group B, median was 624.7 AU/ml and IQR was 621.1 AU/ml (p<0.001). Moreover, participants having comorbidities also showed differences in IgG levels (group A median 2183.20 AU/ml, and IQR of 4095.70 AU/ml; group B median 624.70 AU/ml and IQR of 558.80 AU/ml) (p<0.001). Similarly, among participants with no comorbidities significant differences in IgG levels were observed (group A median 2394.45 AU/ml, and IQR 3450.73 AU/ml; group B median 653.10 AU/ml, and IQR 990.13 AU/ml) (p<0.001). CONCLUSION To conclude, antibody status (serum IgG levels) was found significantly higher in previously infected vaccinated group (group A) compared to non-infected vaccinated group (group B).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".