Contraceptive Potential of Ipomoea asarifolia Aqueous Leaf Extracts in Female Wistar Rats as an Alternative Approach to Rodent Pest Management in Agriculture
Bibliographic record
Abstract
Combined pre- and post-harvest loss in agricultural production accounts for about 40% in Africa with rodent contributing significant damage causing severe economic impact to farmers. This study explores whether Ipomoea asarifolia has contraceptive effects in female Wistar rats as a method of control of rodent pest depredating agricultural produce, by reducing their fertility. The impact of the aqueous leaf extract was assessed on fertility hormones, ovarian structure, and overall physiology in the rat. Forty-five female rats were divided into three groups: a control group and two experimental groups fed with diets containing 200 g/kg and 400 g/kg of I. asarifolia extract for 21 days. Various parameters, including body weight, feed intake, blood composition, hormone levels, and ovarian tissue structure, were analyzed. The results showed no significant changes in body weight or food consumption across the groups (p > 0.05). While some minor variations were observed in haematological and biochemical markers, they were largely insignificant, except for a slight increase in creatinine levels and a decrease in aspartate aminotransferase, which may indicate mild renal and antioxidant effects. Hormonal analysis revealed no substantial changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone, or oestrogen levels (p > 0.05). Histological examination of the ovaries showed some degenerative changes in the group that received the lower dosage, but no abnormalities in the higher dosage group. These findings suggest that I. asarifolia does not have a significant contraceptive effect in female rats within the duration of the study. However, further research using higher doses and longer exposure periods is needed to fully understand its potential anti-reproductive effects.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".