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Record W4412097851 · doi:10.3389/fgwh.2025.1589736

Examination of the proposed relationships between cyclic menstruation and human reproduction

2025· article· en· W4412097851 on OpenAlexaff
Vernon G. Thomas

Bibliographic record

VenueFrontiers in Global Women s Health · 2025
Typearticle
Languageen
FieldImmunology and Microbiology
TopicReproductive System and Pregnancy
Canadian institutionsUniversity of Guelph
FundersMedical Research CouncilUniversity of Edinburgh
KeywordsMenstruationReproductionHuman reproductionMathematicsPsychologyBiologyMedicineEcologyInternal medicineAnatomy

Abstract

fetched live from OpenAlex

Increased societal food security has enabled frequent ovulation based on women's body fat levels remaining above the fertility threshold. The consequential cyclical menstruation in non-pregnant women constitutes a large female health and welfare issue. This examination of the various roles proposed for menstruation could not detect an essential biological role, whether in the removal of un-implanted embryos or the conditioning of the endometrium against oxidative stress. Neither is menstruation a prerequisite for the regeneration of the uterine endometrium. Menstruation and foetal placental detachment from the endometrium at birth share common hormonally-controlled physiological processes initiated by systemic or local progesterone withdrawal. These critical genetically-conserved processes are essential for the survival of both infant and mother. In human ancestors menstruation likely occurred rarely and these processes were activated only during the birth of several children. Now, because of assured food security, the evolved ancestral function of these processes has been reversed, and even allowing for the birth of several children, a woman may experience hundreds of monthly periods in her life. Menstruation is not necessary for a healthy life and women who control hormonally their periods and fertility still retain the physiological capacity for foetal placental detachment, to be expressed should pregnancy occur. This examination's findings could reduce the ignorance and mis-understanding about menstruation and promote, globally, social policy to reduce "period poverty" and absenteeism of girls and women from schools and the workplace.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.003
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.275
Teacher spread0.259 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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