Investigating Airway Symptoms in Eosinophilic Esophagitis ( <scp>EoE</scp> )
Bibliographic record
Abstract
OBJECTIVES: Diagnostic delay of eosinophilic esophagitis (EoE) is significant, and efforts are needed to raise awareness and reduce prolonged symptoms and complications. Airway and swallowing symptoms often overlap, especially in children, complicating diagnosis and increasing delays. This study aims to report the range of airway presentations in pediatric EoE patients and identify independent predictors of an EoE diagnosis in patients with aerodigestive symptoms. METHODS: We conducted a retrospective case-control study of pediatric patients < 7 years with histologically confirmed EoE managed in an aerodigestive clinic at a tertiary pediatric center. Variables included demographics, atopic comorbidities, risk factors, airway and dysphagia symptoms, and adaptive eating behaviors. EoE cases were age-matched to controls with aerodigestive issues and no EoE. Multivariate regression analysis identified independent predictors of EoE. RESULTS: Fifty EoE patients were included, along with 50 controls. The mean age was 2.4 years, with 70% male. Common EoE symptoms included solid food dysphagia (62%), food pocketing (62%), and self-reported food allergies (72%). Airway symptoms included chronic cough (38%) and choking (32%). Multivariate analysis identified food allergy (OR 15.7) and food pocketing (OR 11.81) as independent predictors, while dysphagia with liquids (OR 0.058) and recurrent pneumonia (OR 0.022) were negative predictors. CONCLUSION: Airway symptoms in pediatric EoE can overlap with other conditions, complicating diagnosis. Key features such as adaptive eating behavior and food allergies should raise suspicion for EoE.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".