A.7 A novel Xdystonia-parkinsonism gene variant responsive to bilateral GPi DBS: a video case study
Bibliographic record
Abstract
Background: X-linked dystonia-parkinsonism(XDP) is a rare movement disorder primarily affecting males of Filipino descent characterized by dystonia and parkinsonism. This case illustrates a patient with a novel gene variant responsive to deep brain stimulation (DBS). Methods: Case study of Filipino male with XDP followed for 15 years. Results: A 32-year-old Filipino male presented with oromandibular and cervical dystonia which later generalized. He went on to develop parkinsonism with significant gait impairment, incomprehensible speech, and required PEG tube placement. His symptoms were refractory to pharmacologic therapy. At age 43, he underwent bilateral globus pallidus internus (GPi) DBS placement with significant improvement of his symptoms as illustrated by videos accompanying this report. He had marked improvement of gait, speech, and pharyngeal dystonia resulting in removal of his PEG tube with return to full oral intake. He continues to benefit 3 years after DBS placement. Genetic testing identified a missense hemizygous non-coding transcript exon variant TAF1 n.5776C>T which is a novel gene variant of XDP not previously reported in the literature. Conclusions: This case illustrates a patient with a novel TAF1 gene variant associated with XDP not previously reported in the literature. This variant was responsive to bilateral GPi DBS placement.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".