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Record W4412354157 · doi:10.1101/2025.07.10.25331221

Indigenous, integrative, and biomedical perimenopause and postmenopause healthcare for Indigenous midlife peoples residing in the United States and Canada: A scoping review

2025· review· en· W4412354157 on OpenAlexaboutno aff
Jacqueline Kent‐Marvick, Lisa Taylor‐Swanson, Lydia Howes, Po-Yu Hsu, Sharon Austin, Tumilara Aderibigbe, Leslie Crandall, Madison Elizabeth Maughan, Jessica Ellis, Stephanie Quist, Mary McFarland, Sara E. Simonsen

Bibliographic record

VenuemedRxiv · 2025
Typereview
Languageen
FieldMedicine
TopicMenopause: Health Impacts and Treatments
Canadian institutionsnot available
FundersNational Institutes of HealthNational Institute of Nursing ResearchUniversity of Pennsylvania
KeywordsIndigenousHealth careGerontologyPolitical scienceGeographySociologyEconomic growthMedicineLawEconomics

Abstract

fetched live from OpenAlex

Abstract Background Little is known about the menopause-related healthcare of Indigenous people of the United States and Canada. This scoping review mapped the existing literature on Indigenous, integrative, and biomedical healthcare for U.S.- and Canada-based perimenopausal Indigenous populations. Methods We followed the JBI Manual for Evidence Synthesis. The protocol was registered on Open Science Framework. Eligibility criteria included records focused on Indigenous people of the U.S. and Canada perimenopause/postmenopause healthcare. Medline and eight other data bases were searched on June 1, 2023, and updated November 21, 2024. Covidence was used for selecting and extracting data. Findings After screening 6,684 records, 45 met inclusion criteria. These focused on Indigenous people’s experiences, care barriers, symptom reporting, and treatment preferences. Traditionality, community roles, and cultural beliefs influenced symptom experience and healthcare-seeking. Many participants preferred Indigenous or integrative interventions, sometimes in combination with biomedical care. Barriers included rushed encounters, language and cultural disconnects, and systemic inequities. Interpretation Findings highlight the need for culturally responsive, patient-centered care during the menopausal transition with an emphasis on evidence-based interventions including Indigenous and integrative health approaches. Additional research, stronger community engagement, and healthcare-provider training will help improve perimenopause health outcomes for Indigenous populations in the United States and Canada Funding The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article. The first author received support from the National Clinician Scholars Program (NCSP) as a postdoctoral fellow at the University of Pennsylvania. Additionally, she was supported by the National Institute of Nursing Research of the National Institutes of Health under Award Number F31NR020431. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the Indian Health Service. The authors were supported by a grant from the University of Utah office of the Vice President for Research. Panel: Research in Context Evidence before this study Before undertaking this scoping review, the review team identified several sentinel articles. No prior evidence reviews nor protocols on our topic were identified in searches conducted on February 22, 2023 in PROSPERO, Open Science Framework, PubMed, Cochrane Library, Campbell Systematic Reviews, CINAHL, and Sociological Abstracts. We then conducted comprehensive searches across nine databases—Medline (Ovid) 1946-2024, Embase (Elsevier) 1974-2024, CINAHL Complete (EBSCOhost) 1937-2024, Ageline (EBSCOhost) 1966-2024, Alt HealthWatch (EBSCOhost) 1984-2024, APA PsycInfo (EBSCOhost) 1872-2024, Scopus (Elsevier) 1977-2024, Web of Science Core Collection (Clarivate) 1900-2024, and the Native Health Database (1900-2024). Searches were initially conducted on June 1, 2023, and repeated on November 21, 2024. We also reviewed reference lists of included studies. Search strategies combined keywords and subject headings related to menopause, healthcare, and Indigenous populations. Only English-language records were included due to funding constraints. We excluded books and cancer-related studies to focus on natural or surgical menopause not induced by chemotherapy. No quality assessment of included studies was conducted in accordance with scoping-review methodology. Added value of this study This is the first known scoping review to synthesize literature on perimenopause and postmenopause healthcare among Indigenous peoples in the United States and Canada. It maps Indigenous, integrative, and biomedical treatment practices; highlights structural and cultural barriers to care; and identifies the influence of traditional knowledge, community roles, and colonization on symptom interpretation and treatment-seeking. It also summarizes patient-centered recommendations for improving perimenopause healthcare delivery, and outlines key research gaps. Implications of all the available evidence Findings from this review, combined with existing literature, emphasize the urgent need for culturally responsive, community-informed healthcare for Indigenous midlife populations. Interventions should consider traditional knowledge systems, language and literacy needs, and preferences for Indigenous and integrative treatments. Healthcare providers must engage in shared decision-making and address systemic barriers to care. Future research should center Indigenous perspectives, investigate disparities in symptom experiences, and help to improve access to perimenopause healthcare for Indigenous peoples.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.019
metaresearch head score (Gemma)0.071
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.251
Threshold uncertainty score0.505

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0190.071
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0040.003
Bibliometrics0.0180.025
Science and technology studies0.0040.002
Scholarly communication0.0070.003
Open science0.0020.003
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0050.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.392
Teacher spread0.338 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations1
Published2025
Admission routes1
Has abstractyes

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