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Record W4412366971 · doi:10.1186/s12982-025-00806-0

Fit-for-purpose solutions beyond supervised injection offer the next stage of harm reduction for the US drug epidemic

2025· article· en· W4412366971 on OpenAlexaboutno aff
H Bard, Avik Chatterjee

Bibliographic record

VenueDiscover Public Health · 2025
Typearticle
Languageen
FieldMedicine
TopicHIV, Drug Use, Sexual Risk
Canadian institutionsnot available
Fundersnot available
KeywordsHarm reductionReduction (mathematics)HarmDrugRisk analysis (engineering)MedicineComputer scienceIntensive care medicinePharmacologyVirologyPolitical scienceMathematicsLawHuman immunodeficiency virus (HIV)

Abstract

fetched live from OpenAlex

Overdose Prevention Centers (OPCs) provide critical harm reduction services for people who use drugs. For over twenty years, such centers, including supervised injection facilities, have proven to be successful tools for combating drug epidemics with well-demonstrated benefits of reducing overdose deaths and the transmission of infectious disease such as HIV in participating communities in Europe, Australia, and Canada. Although there are limited exceptions in the US, the controversial nature of OPCs has prevented adoption across the country, thereby contributing to large numbers of preventable deaths. Analysis of CDC overdose death data demonstrates that the drug types causing deaths are highly variable by state and that while opioids (primarily fentanyl) are the most important contributor, a significant portion of overdose deaths do not involve opioids and are likely to involve other modes of consumption in addition to injection. Considering this finding, arguments are made for policy and facility strategy changes that would lead to development of new fit-for-purpose OPCs that are best suited to specific regions and likely more acceptable to individuals within these communities. Tailoring OPCs could accelerate destigmatization and increase adoption of OPCs in urban and non-urban communities to effectively manage this nationwide epidemic.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.269
Threshold uncertainty score0.541

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.149
GPT teacher head0.401
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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