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Record W4412400098 · doi:10.1073/pnas.2422742122

Dynamic neuroplasticity of language networks: The intersection of bilingualism and epilepsy

2025· article· en· W4412400098 on OpenAlexaff
Alena Stasenko, Erik Kaestner, Adam Schadler, Anny Reyes, Clare Urbanic, Jonathan L. Helm, Daniel G Saldana, Giselle Carollo-Duprey, Monika Połczyńska, Christopher Benjamin, Leigh Sepeta, Tamar H. Gollan, Lucia Cavanagh, Carrie R. McDonald

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2025
Typearticle
Languageen
FieldNeuroscience
TopicNeurobiology of Language and Bilingualism
Canadian institutionsVancouver General Hospital
FundersNational Institute of Neurological Disorders and StrokeNational Institute on AgingNational Institutes of Health
KeywordsLateralization of brain functionEpilepsyPsychologyNeuroscience of multilingualismLateralityContext (archaeology)NeuroscienceNeuroplasticityCognitive psychologyAudiologyMedicine

Abstract

fetched live from OpenAlex

Are bilingual language networks flexible enough to dynamically adapt to neurological insult? We examined language lateralization in 24 bilingual and 46 monolingual adults with temporal lobe epilepsy using functional MRI. In a group of primarily early sequential bilingual patients, the first acquired language (L1) showed more bilateral lateralization than in monolingual patients, with no effect of seizure onset laterality. In contrast, the second-acquired language (L2) was more bilateral in the presence of left hemisphere epilepsy and more left-lateralized in right hemisphere epilepsy. Most notably, in left hemisphere epilepsy, seizure onset closer to L2 acquisition was associated with more right-lateralized L2 representation. These findings suggest a compensatory process in which L2 networks strengthen in the hemisphere opposite the seizure focus, potentially reflecting neural adaptation in early bilingualism. Conversely, L1 appears to have less dynamic reorganization in response to neurological insult. Together, these findings highlight the importance of timing in both language experience and neurological stress in shaping language network organization. They support the view that the bilingual brain is not simply the sum of two monolingual systems, but a dynamic and unique system marked by high interindividual variability, in which divergence between languages may emerge under certain experience- and context-dependent conditions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.314
Teacher spread0.292 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueProceedings of the National Academy of Sciences→Same topicNeurobiology of Language and Bilingualism→French-language works237,207→