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Record W4412427136 · doi:10.1002/edn3.70158

Impact of <scp>CO<sub>2</sub></scp>‐Induced Aquatic Acidification on Environmental <scp>DNA</scp> and <scp>RNA</scp> Shedding and Persistence

2025· article· en· W4412427136 on OpenAlexafffund
Mark Louie D. Lopez, Kate Rolheiser, Jacob Etzkorn, Jacob J. Imbery, Matthew A. Lemay, Iria Gimenez, Caren C. Helbing

Bibliographic record

VenueEnvironmental DNA · 2025
Typearticle
Languageen
FieldEnvironmental Science
TopicEnvironmental DNA in Biodiversity Studies
Canadian institutionsUniversity of Victoria
FundersHakai InstituteLiber Ero FoundationGenome CanadaTula FoundationAlliance de recherche numérique du CanadaGenome British Columbia
KeywordsPersistence (discontinuity)RNADNAChemistryBiologyCell biologyGeneGenetics

Abstract

fetched live from OpenAlex

ABSTRACT Anticipated future increases in CO 2 levels are predicted to have a diverse array of lethal and non‐lethal effects on the marine ecosystem. While there has been extensive research on the physiological impacts of ocean acidification on marine species, our understanding of how increasing levels of carbon dioxide affect the shedding and decay of environmental DNA and RNA (eDNA/eRNA) in marine habitats is limited. This may impede the effective adoption of environmental nucleic acid–based molecular tools for monitoring marine biodiversity and detecting rare or invasive species. In the present study, we conducted mesocosm experiments to determine the shedding and decay rate constants of eDNA and eRNA in M. gigas ( Magallana [ Crassostrea ] gigas ) using mitochondrially encoded tRNA leucine 1 ( mt‐tl1 ) marker at various partial pressures of CO 2 in seawater. To our knowledge, this is the first study manipulating seawater pH using CO 2 . We developed a sensitive and specific quantitative PCR‐based assay to detect M. gigas eDNA and eRNA. Higher CO 2 levels increased shedding rates, indicating greater organism stress and biological effects on oysters. Additionally, increased CO 2 accelerates DNA and RNA decay, suggesting that ocean acidification may impact the reliability of eDNA‐based biodiversity monitoring. Furthermore, eRNA displayed lower steady‐state concentrations and a shorter persistence time in comparison to eDNA, as is consistent with known biochemical properties of the molecules. These findings are presented in the context of previous work that adjusted pH through acid–base adjustment and temperature and highlight the importance of considering ocean acidification caused by differing CO 2 levels when using molecular tools for marine conservation and fisheries management.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.222
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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