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Record W4412427136 · doi:10.1002/edn3.70158

Impact of <scp>CO<sub>2</sub></scp>‐Induced Aquatic Acidification on Environmental <scp>DNA</scp> and <scp>RNA</scp> Shedding and Persistence

2025· article· en· W4412427136 on OpenAlexafffund
Mark Louie D. Lopez, Kate Rolheiser, Jacob Etzkorn, Jacob J. Imbery, Matthew A. Lemay, Iria Gimenez, Caren C. Helbing

Bibliographic record

VenueEnvironmental DNA · 2025
Typearticle
Languageen
FieldEnvironmental Science
TopicEnvironmental DNA in Biodiversity Studies
Canadian institutionsUniversity of Victoria
FundersHakai InstituteLiber Ero FoundationGenome CanadaTula FoundationAlliance de recherche numérique du CanadaGenome British Columbia
KeywordsPersistence (discontinuity)RNADNAChemistryBiologyCell biologyGeneGenetics

Abstract

fetched live from OpenAlex

ABSTRACT Anticipated future increases in CO 2 levels are predicted to have a diverse array of lethal and non‐lethal effects on the marine ecosystem. While there has been extensive research on the physiological impacts of ocean acidification on marine species, our understanding of how increasing levels of carbon dioxide affect the shedding and decay of environmental DNA and RNA (eDNA/eRNA) in marine habitats is limited. This may impede the effective adoption of environmental nucleic acid–based molecular tools for monitoring marine biodiversity and detecting rare or invasive species. In the present study, we conducted mesocosm experiments to determine the shedding and decay rate constants of eDNA and eRNA in M. gigas ( Magallana [ Crassostrea ] gigas ) using mitochondrially encoded tRNA leucine 1 ( mt‐tl1 ) marker at various partial pressures of CO 2 in seawater. To our knowledge, this is the first study manipulating seawater pH using CO 2 . We developed a sensitive and specific quantitative PCR‐based assay to detect M. gigas eDNA and eRNA. Higher CO 2 levels increased shedding rates, indicating greater organism stress and biological effects on oysters. Additionally, increased CO 2 accelerates DNA and RNA decay, suggesting that ocean acidification may impact the reliability of eDNA‐based biodiversity monitoring. Furthermore, eRNA displayed lower steady‐state concentrations and a shorter persistence time in comparison to eDNA, as is consistent with known biochemical properties of the molecules. These findings are presented in the context of previous work that adjusted pH through acid–base adjustment and temperature and highlight the importance of considering ocean acidification caused by differing CO 2 levels when using molecular tools for marine conservation and fisheries management.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.260
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0010.002
Scholarly communication0.0000.001
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.222
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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