Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 administration to Long–Evans rats has interactive effects with sex and diet on anxiety-related feeding behaviors and specific endocrine outcomes
Bibliographic record
Abstract
Anxiety symptomatology and metabolic functioning are intricately related, with associated mechanisms yet to be fully delineated. Nutritional manipulations may influence these outcomes in a sex-specific manner. This study characterized the interactive effects of the Cerebiome® probiotic and the D12079B-formulated Western diet (WD) on anxiety- and feeding-related behaviors and physiological outcomes in 80 male and female Long-Evans rats born to dams also administered either the probiotic or placebo during gestation and lactation. In WD-fed rats, the probiotic attenuated the increase in daily calorie intake observed in placebo rats. Subsequently, in the novelty-suppressed feeding task (NSFT), probiotic standard diet (SD) males spent more time in the center of an open field, suggesting a reduced anxiety-related state. Independent of diet and sex, probiotic administration resulted in more feeding bouts and food pellet contacts in the center compared to placebo. Furthermore, independent of probiotic and sex, WD rats lost less weight following the 24 h fast prior to behavioral testing and consumed more calories during the NSFT compared to SD rats. At sacrifice, rats given Cerebiome® had higher adrenal neuropeptide Y expression than placebo, and females had higher adrenal glucocorticoid receptor expression than males. In plasma, leptin was increased with WD and ghrelin was increased in SD females. These findings demonstrate that the Cerebiome® probiotic and this specific WD differentially affect behavioral and physiological indicators of health. We additionally demonstrate that concurrently administered nutritional factors interact to affect study outcomes based on sex, supporting the inclusion of both sexes in similar preclinical nutrition research.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".