Increased population receptive field size in early visual cortex following the loss of one eye
Bibliographic record
Abstract
The surgical removal of one eye (monocular enucleation) early in life results in partial visual deprivation and offers a unique model for examining the consequences of the loss of binocularity on the maturation of the visual system. Adults who have undergone early monocular enucleation exhibit several long-term visual, auditory, and audiovisual behavioural adaptations as well as structural and functional adaptations within and between cortical and subcortical regions. In the current study, we investigated whether topographically organized visual cortex is influenced by the reduction in input to the visual system following monocular enucleation. We used functional Magnetic Resonance Imaging (fMRI) to map population Receptive Fields (pRFs) in individuals who have had one eye removed, as well as binocularly intact controls. pRF mapping was performed using a standard checkerboard bar swept across the visual field while participants performed a central fixation task. For each location on the cortical surface, we determined the size and visual field location of the pRF that accounted for the maximum variance in the observed fMRI signal. In early visual areas (V1, V2, and V3) of both hemispheres, pRFs were systematically larger for people with one eye compared to controls. Additionally, there was a larger rate of pRF expansion with eccentricity in the hemisphere contralateral to the remaining eye. No differences were observed for other parameters, including overall model fit, eccentricity, or gain. In summary, monocular enucleation may induce sensory plasticity where neurons in early visual cortex respond to a larger portion of the visual world. This is consistent with previous reports of reorganization within the LGN contralateral to the remaining eye and increased surface area in the primary visual cortex following monocular enucleation. These findings, in conjunction with behavioural and neuroimaging studies, contribute to the broader understanding of the effects of sensory deprivation from eye enucleation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".