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Record W4412532612 · doi:10.1162/imag.a.98

EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data

2025· article· en· W4412532612 on OpenAlex
Rohan Banerjee, Merve Kaptan, Alexandra Tinnermann, Ali Khatibi, Alice Dabbagh, Christian Büchel, Christian W. Kündig, Christine Law, Dario Pfyffer, David J. Lythgoe, Dimitra Tsivaka, Dimitri Van De Ville, Falk Eippert, Fauziyya Muhammad, Gary H. Glover, Gergely Dávid, Grace Haynes, Jan Haaker, J.C. Brooks, Jürgen Finsterbusch, Katherine T. Martucci, Kimberly J. Hemmerling, Mahdi Mobarak-Abadi, Mark A. Hoggarth, Matthew A. Howard, Molly G. Bright, Nawal Kinany, Olivia S. Kowalczyk, Patrick Freund, Robert Barry, Sean Mackey, Shahabeddin Vahdat, Simon Schading‐Sassenhausen, Stephen B. McMahon, Todd Parish, Véronique Marchand‐Pauvert, Yufen Chen, Zachary A. Smith, Kenneth A. Weber, Benjamin De Leener, Julien Cohen‐Adad

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueImaging Neuroscience · 2025
Typearticle
Languageen
FieldEngineering
TopicMedical Imaging and Analysis
Canadian institutionsUniversité de MontréalCentre Hospitalier Universitaire Sainte-JustineMcGill UniversityMila - Quebec Artificial Intelligence InstituteMontreal Neurological Institute and HospitalInstitut Universitaire de Gériatrie de MontréalPolytechnique Montréal
FundersNational Center for Complementary and Integrative HealthNational Institute of Neurological Disorders and StrokeNational Institute of Biomedical Imaging and BioengineeringFonds de Recherche du Québec - SantéNational Science FoundationCanadian Institutes of Health ResearchNatural Sciences and Engineering Research Council of CanadaNational Institute on Drug AbuseInstitut de Valorisation des DonnéesNational Institutes of HealthCanada First Research Excellence FundPolytechnique MontréalSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungCanada Foundation for InnovationCenter for Bio-Inspired Energy Science, Northwestern UniversityCraig H. Neilsen Foundation
KeywordsSegmentationEcho (communications protocol)Center (category theory)PlanarEcho-planar imagingArtificial intelligenceComputer visionSpinal cordComputer scienceMedicineMagnetic resonance imagingRadiologyComputer graphics (images)ChemistryComputer network

Abstract

fetched live from OpenAlex

Functional magnetic resonance imaging (fMRI) of the spinal cord is relevant for studying sensation, movement, and autonomic function. Preprocessing of spinal cord fMRI data involves segmentation of the spinal cord on gradient-echo echo planar imaging (EPI) images. Current automated segmentation methods do not work well on these data, due to the low spatial resolution, susceptibility artifacts causing distortions and signal drop-out, ghosting, and motion-related artifacts. Consequently, this segmentation task demands a considerable amount of manual effort which takes time and is prone to user bias. In this work, we (i) gathered a multi-center dataset of spinal cord gradient-echo EPI with ground-truth segmentations and shared it on OpenNeuro https://openneuro.org/datasets/ds005143/versions/1.3.1 and (ii) developed a deep learning-based model, EPISeg, for the automatic segmentation of the spinal cord on gradient-echo EPI data. We observe a significant improvement in terms of segmentation quality compared with other available spinal cord segmentation models. Our model is resilient to different acquisition protocols as well as commonly observed artifacts in fMRI data. The training code is available at https://github.com/sct-pipeline/fmri-segmentation/, and the model has been integrated into the Spinal Cord Toolbox as a command-line tool.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.934
Threshold uncertainty score0.425

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0020.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.119
GPT teacher head0.435
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it