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Examining cross-lag associations between perceived stress and hair cortisol from pregnancy to 15 months postpartum

2025· article· en· W4412595061 on OpenAlexafffund
Jennifer E. Khoury, Marc Jambon, Andrea González, Leslie Atkinson

Bibliographic record

VenuePsychoneuroendocrinology · 2025
Typearticle
Languageen
FieldNeuroscience
TopicStress Responses and Cortisol
Canadian institutionsMcMaster UniversityToronto Metropolitan UniversityWilfrid Laurier UniversityMount Saint Vincent University
FundersCanadian Institutes of Health ResearchCanada Research Chairs
KeywordsPregnancyLagObstetricsMedicineEndocrinologyPsychologyInternal medicineBiology

Abstract

fetched live from OpenAlex

BACKGROUND: The perinatal period is often characterized by heightened psychological and biological stress. While psychological distress and neuroendocrine (hypothalamic pituitary adrenal, HPA) activity are often assumed to be interrelated, perceived stress and hair cortisol concentrations, a marker of longer-term HPA activity, are inconsistently associated during the perinatal period. This longitudinal study investigates the concurrent, prospective, and cross-lagged associations between maternal perceived stress and HCC from pregnancy through 15 months postpartum. METHODS: Individuals (n = 304) participated at different points during pregnancy and at 6 weeks, 6 months, and 15 months postpartum. At each time point, self-reported perceived stress and hair samples were collected. Correlational analyses and cross-lagged panel analyses were used to evaluate the stability of perceived stress and hair cortisol over time, as well as the concurrent and cross-lagged associations. RESULTS: Both perceived stress and HCC showed strong stability across time points. The only significant cross-lagged association was between higher HCC at 6 weeks postpartum predicting higher perceived stress at 6 months. No other cross-lagged or concurrent associations between HCC and perceived stress were significant. CONCLUSIONS: These findings highlight the stability of maternal perceived stress and HCC from pregnancy to 15 months postpartum. We did not find strong support for concurrent or cross-lagged associations between HCC and perceived stress during the perinatal period, suggesting potential distinct biological and psychosocial contributors to psychological and neuroendocrine markers of stress.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.080
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.052
GPT teacher head0.337
Teacher spread0.285 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes2
Has abstractyes

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