Distinct Brain Electrical Activity Patterns in Dominant and Submissive Mice: Implications for Cognitive Impairments
Bibliographic record
Abstract
The prefrontal, visual, and posterior parietal cortices are key to cognition, social interaction, and novelty recognition, but the impact of social hierarchy and inherent stress sensitivity on their interplay remains underexplored. Our findings reveal significant neural differences between stress-resilient dominant (Dom) and stress-sensitive submissive (Sub) mice, particularly in theta band power, inter-regional coherence, and phase-amplitude coupling. Dom mice exhibited reduced theta coherence and dynamic changes in theta-gamma phase amplitude coupling between the prefrontal and visual cortices, which were associated with better memory recall and cognitive flexibility. In addition, Dom mice showed increased left-to-right visual cortex connectivity during the recognition task, linked to successful novelty discrimination, while Sub mice lacked this theta-driven causality. These results suggest that stress sensitivity associated with social rank alters neural activity and connectivity, contributing to the differing performance of Dom and Sub mice in novelty recognition tasks, providing potential diagnostic and therapeutic implications for targeting theta-driven connectivity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".