Macrovascular Hemodynamics and Peripheral Perfusion in Cardiogenic Shock
Bibliographic record
Abstract
Despite significant advances in care over the past few decades, mortality among patients with cardiogenic shock (CS) remains up to 50%. Given the persistently high mortality, there is an urgent need for both better prognostic tools and treatment strategies. The pathophysiology of CS has major contributions from both macrovascular and microvascular dysfunction, but therapies are titrated toward the more readily measurable metrics (ie, mean arterial pressure, cardiac index, etc) under the assumption that both macrovascular and microvascular dynamics will respond to intervention in tandem. However, emerging evidence suggests that macrovascular and microvascular circulatory functions are not always aligned, particularly in those with critical illness. This review summarizes the significance of different macrovascular and microvascular metrics in CS, drawing from a robust field of evidence to demonstrate the promising role that microvascular tissue perfusion markers play in management of patients with CS and summarize the current understanding of this burgeoning field.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".