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Record W4412622292 · doi:10.1021/acs.chemmater.5c00127

Synthesis of Highly Ordered Amphiphilic Polymer Conetwork Hydrogels via the Topologically Precise Interconnection of Two Highly Incompatible Polymers

2025· article· en· W4412622292 on OpenAlexaff
Demetris E. Apostolides, George Michael, Konstantinos Andronikou, Costas S. Patrickios, Szabolcs Pásztor, Györgyi Szarka, Anna Petróczy, Béla Iván, Takamasa Sakai, Sylvain Prévost, Dimitrios G. Tsalikis, Michael Gradzielski

Bibliographic record

VenueChemistry of Materials · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicHydrogels: synthesis, properties, applications
Canadian institutionsInstitute of Particle Physics
FundersNational Research, Development and Innovation OfficeResearch and Innovation FoundationEuropean Regional Development FundNemzeti Kutatási Fejlesztési és Innovációs HivatalDirectorate General for European Programmes, Coordination and Development
KeywordsPolymerSelf-healing hydrogelsAmphiphileInterconnectionMaterials sciencePolymer sciencePolymer chemistryNanotechnologyCopolymerComputer scienceComposite material

Abstract

fetched live from OpenAlex

Here, hydrophobic polyisobutylene and hydrophilic poly-(ethylene glycol), both of reasonably high molar masses, have been end-linked, yielding amphiphilic polymer conetwork (APCN) hydrogels that can self-organize in water into well-ordered lamellar structures. The cross-linking of hydrophobic and hydrophilic polymer segments produces networks that typically exhibit sphere-like nanodomains in water and in the bulk, but the orderly interconnection of relatively large and highly incompatible polymers leads to hydrogels that internally assemble into lamellae. This unprecedented result may be attributed to the weak force-field established by the presence of a minimal concentration of homogeneously distributed cross-links in the case of the present system, which must be contrasted to a higher concentration of randomly placed cross-linking points, which destroy long-range ordering in conventional APCN hydrogels. Significantly, the presently developed APCN hydrogels maintain good tensile mechanical properties, with their strain-at-break reaching a value of 800%. This study puts forward the design concepts for attaining highly ordered hydrogels, which would confer upon them better transport and mechanical properties and broaden their utility in biomedical and energy applications.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.000
Threshold uncertainty score0.002

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.242
Teacher spread0.232 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2025
Admission routes1
Has abstractyes

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