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Record W4412674911 · doi:10.1101/2025.07.25.25331837

Standards for Reporting of Diagnostic Accuracy involving Intraoperative Neurophysiological Monitoring

2025· preprint· en· W4412674911 on OpenAlexaff
Parthasarathy D. Thirumala, Anthony Absalom, Stefanie Binzer, Michael G. Fehlings, Isabel Fernández-Conejero, Lanjun Guo, Robert N. Holdefer, E. Matthew Hoffman, Marc R. Nuwer, Kyung Seok Park, Julian Prell, Francesco Sala, Nishanth Sampath, Daniel SanJuan-Orto, Jay L. Shils, Mirela V. Simon, Christoph N. Seubert, Silvia Mazzali Verst, Patrick M. Bossuyt

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldMedicine
TopicHemodynamic Monitoring and Therapy
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsIntraoperative neurophysiological monitoringNeurophysiologyMedicineComputer scienceMedical physicsPsychologyNeuroscienceAnesthesia

Abstract

fetched live from OpenAlex

Title Standards for Reporting of Diagnostic Accuracy using Intraoperative Neurophysiological Monitoring (STARD-IONM) Objective Intraoperative neurophysiological monitoring (IONM) plays a critical role in preserving functional integrity during surgery, yet it is challenging to compare studies due to methodological heterogeneity and inconsistent reporting. We developed the STARD-IONM extension to improve the transparency, completeness, and comparability of IONM studies. Methods The STARD-IONM initiative followed a three-phase consensus. Phase 1 convened a IONM expert panel to discuss and define the rationale and scope. Phase 2 involved structured item-level review of existing STARD items in the context of IONM, applied to published studies with iterative feedback. Phase 3 will include broader community engagement via preprints, outreach to professional societies, and public commentary. Results A systematically selected review of IONM studies revealed the underreporting of at key methodological items such as handling missing data (7%), adverse events (11%), and blinding of test and outcomes (22%). A STARD-IONM checklist with recommendations for reporting IONM studies with IONM specific examples were developed. Community feedback emphasized challenges unique to IONM, including the classification of reversible IONM changes, and variability in reference standards. Conclusions The STARD-IONM framework addresses critical gaps in the reporting of diagnostic accuracy studies involving IONM. It represents an application of the STARD criteria, wherein the original checklist has been adapted and supplemented with guidelines for IONM studies. Significance Standardized reporting will facilitate enhanced adherence to methodological standards, increase reproducibility and strengthen the evidence base for the safe and effective use of IONM, which is expected to improve clinical decision-making.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.048
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.217
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.048
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.063
GPT teacher head0.395
Teacher spread0.332 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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