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Record W4412691512 · doi:10.1002/alz.70524

Social determinants of dementia: A scoping review

2025· review· en· W4412691512 on OpenAlexafffund
Sebastian Walsh, Matthias Klee, Esther K. Hui, Usman Saeed, Sheena Waters, Isla Kuhn, Joyce Siette, Vasiliki Orgeta, Jean Stafford, Laura Smith, Stefano Tamburin, Daria E. A. Jensen, Elisa Mantovani, Avinash Chandra, Sarah‐Naomi James, Eugene Tang, David J. Llewellyn, Isabelle F. Foote, Scott T. Chiesa, Anouk F.J. Geraets

Bibliographic record

VenueAlzheimer s & Dementia · 2025
Typereview
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsUniversity of TorontoSunnybrook Health Science Centre
FundersNational Institute for Health Research Applied Research Collaboration South West PeninsulaEconomic and Social Research CouncilUniversity of TorontoNational Institute on AgingDeutsche ForschungsgemeinschaftUniversity College London Hospitals NHS Foundation TrustEuropean CommissionNational Institute for Health and Care ResearchAlzheimer's Society
KeywordsDementiaSocioeconomic statusPsychological interventionSocial determinants of healthEthnic groupGerontologyPublic healthSystematic reviewPsychologyMedicineEnvironmental healthMEDLINESociologyPolitical sciencePsychiatryDiseasePopulation

Abstract

fetched live from OpenAlex

Dementia risk is influenced by the social conditions in which people live. These social determinants of dementia (SDOD) are potential targets for prevention. We conducted a comprehensive scoping review to identify current evidence on SDOD in two stages: (1) review of systematic reviews on SDOD; and (2) review of primary literature to address identified gaps in the evidence base. Of the 3445 articles screened, 26 reviews and 74 primary studies were included. Evidence from reviews provide clear and consistent patterns for some SDOD (e.g., education, air pollution, socioeconomic status, ethnicity), while evidence for others is still emerging (e.g., housing quality/stability), or lacking entirely (e.g., incarceration). SDOD are important over the life course. Additional evidence is needed for understudied domains and to unravel the complex interactions between determinants, whilst education and air pollution stand out as key targets for public health interventions. HIGHLIGHTS: There is clear and consistent evidence for some social determinants of dementia (SDOD) across diverse domains. Evidence for other SDOD (e.g., housing, incarceration) is still emerging or lacking. Evidence for SDOD comes mainly from high-income countries. The complex intercorrelations between SDODs demand a nuanced analytical approach. Standardized measures and longer follow-up to study SDOD are recommended.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.007
metaresearch head score (Gemma)0.025
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.014
Threshold uncertainty score0.035

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0070.025
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0050.006
Bibliometrics0.0140.012
Science and technology studies0.0010.001
Scholarly communication0.0030.003
Open science0.0020.002
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.097
GPT teacher head0.451
Teacher spread0.354 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations15
Published2025
Admission routes2
Has abstractyes

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