Bibliographic record
Abstract
ABSTRACT Polyion complex (PICs) micelles are formed through the self‐assembly of polyelectrolytes bearing opposite charges. The ability to form PICs under fully aqueous conditions makes them attractive for the encapsulation of biopolymers such as proteins and nucleic acids for potential therapeutic applications. Stimuli‐responsive PIC micelles have the potential to release their cargo under specific biological conditions. We describe here the development of PIC micelles formed from two self‐immolative polymers (SIPs) with complementary charges. The polycationic SIP, having pendent ammonium groups, undergoes depolymerization in response to light. The polyanionic SIP, bearing pendent carboxylates and a stabilizing PEG block, undergoes depolymerization in response to a pH change from 7.4 to 6. SIP PICs composed of a 0.6 anion:cation ratio remain well dispersed at pH 7.4, but degrade at pH 6, primarily due to depolymerization of the anionic block. Irradiation with UV light leads primarily to depolymerization of the cationic block. In vitro cytotoxicity assays with C2C12 cells indicate that the PICs are quite well tolerated by the cells with low cytotoxicity up to about 0.5 mg mL −1 . Overall, these PICs are a new platform that can potentially be used for the encapsulation and stimulus‐mediated release of ionic cargo.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".