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Record W4412714509 · doi:10.1016/j.onehlt.2025.101147

229E- and NL63-like coronaviruses in phyllostomid bats, Belize

2025· article· en· W4412714509 on OpenAlexaff
B. R. Ansil, Guang-Sheng Lei, Michael Letko, Stephanie N. Seifert, M. Brock Fenton, Nancy B. Simmons, Ryan F. Relich, Daniel J. Becker

Bibliographic record

VenueOne Health · 2025
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicBat Biology and Ecology Studies
Canadian institutionsWestern University
FundersUniversity of OklahomaEdward Mallinckrodt, Jr. FoundationHuman Frontier Science ProgramIndiana UniversityNational Geographic SocietyAmerican Museum of Natural History
KeywordsCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakBiologyCoronavirusGeographyZoologyVirologyMedicinePathologyOutbreakInfectious disease (medical specialty)

Abstract

fetched live from OpenAlex

Coronaviruses (CoVs) are a diverse group of RNA viruses that infect a broad range of hosts, including many bat species. The emergence of several CoVs, specifically α-CoVs and β-coVs causing significant human and domestic animal diseases, has been linked to bats. Characterizing the evolutionary relationships and host associations of bat-borne CoVs is crucial for understanding and mitigating zoonotic risks. While most bat CoV research has focused on the Eastern Hemisphere, the diversity of CoVs in Neotropical bats remains relatively understudied. Here, we report novel and previously identified α-CoV diversity in three phyllostomid bats ( Desmodus rotundus , Carollia sowelli , and Sturnira parvidens ) in Belize. Our analysis targeting the partial RNA-dependent RNA polymerase gene revealed varying prevalence (22.22 - 36.36 %) across these species. Our phylogenetic analysis suggests strong similarity between two Neotropical bat α-CoV lineages and human CoVs (229E and NL63), illustrating new evolutionary relationships compared to prior bat α-CoVs.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.099
Threshold uncertainty score0.197

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.277
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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