Summary of best evidence for safe management of vasopressors through peripheral intravenous catheters
Bibliographic record
Abstract
BACKGROUND: Vasopressors are critical for maintaining hemodynamic stability in critically ill patients, traditionally administered via central venous catheters (CVCs). However, CVCs carry risks of complications and insertion delays. Peripheral intravenous catheters (PIVCs) offer a rapid alternative but pose risks of extravasation and phlebitis. This study aimed to evaluate and summarize the evidence for the safe management of vasopressors through peripheral intravenous catheters, providing reference for clinical practice. METHODS: This evidence summary utilized the standard evidence summary report of Fudan University Center for Evidence-based Nursing, which includes problem establishment, evidence retrieval, literature screening, quality evaluation of the literature, the summary and grading of evidence. The registration number is "ES20246694". Current literatures were systematically searched for the best evidence for safe management of vasopressors through PIVCs. BMJ Best Practice, UpToDate, DynaMed, Joanna Briggs Institute, Cochrane Library, Guidelines International Network, National Institute for Health and Clinical Excellence, Scottish Intercollegiate Guidelines Network, Registered Nurses' Association of Ontario, Intravenous Nurses Society, Chinese Nursing Association, PubMed, Embase, CINHAL, Web of Science, Chinese Medical Journal Full-text Database, Sinomed, CNKI, Wanfang, and VIP were searched from database establishment to 27 June 2025. Literature types included clinical practice guidelines, clinical decisions, expert consensuses, systematic reviews, and evidence summaries. RESULTS: Our systematic search retrieved 1,925 publications, and finally identified 12 articles that had high-quality results. The evidence synthesis comprised three clinical decisions, four guidelines, one expert consensus, and four systematic reviews. We summarized the 29 pieces of best evidence from these articles, covering five aspects: training and education, infusion site selection, vascular access placement, infusion regimen optimization, and complication management. Of these pieces of evidence, 23 were 'strong' and 6 were 'weak', 9 pieces of evidence were recommended in level one. CONCLUSION: The following 29 pieces of evidence for safe management of vasopressors through peripheral intravenous catheters were finally recommended. However, due to the multinational origin of the evidence, feasibility, appropriateness, clinical significance, and effectiveness must be evaluated within institutional contexts prior to implementation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".