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Wharton’s Jelly Tissue Allografts for Tearing in the Plantar Fascia

2025· preprint· en· W4412813444 on OpenAlexaboutno aff
Babak Baravarian, Gina P. Kwon, Conrad Tamea, John Shou, Naomi Lambert, Alexis Lee, Eva Castle, Tyler W. Barrett

Bibliographic record

VenuePreprints.org · 2025
Typepreprint
Languageen
FieldMedicine
TopicTendon Structure and Treatment
Canadian institutionsnot available
Fundersnot available
KeywordsTearingFasciaWharton's jellyDeep fasciaAnatomyMedicineMaterials scienceComposite material

Abstract

fetched live from OpenAlex

Introduction: Plantar fasciitis (PF) or plantar fasciopathy is the most common cause of heel pain in adults. 10% of the general population is affected by some severity of plantar fasciopathy. Current standard-of-care methods, both conservative and non-conservative, provide a variety of complications and side effects. Current methods are not cost-effective, with the total annual expenditure of $284 million in PF standard care. The purpose of this observational study is to evaluate the efficacy of Wharton’s jelly (WJ) when applied to defects in the plantar fascia. Materials and Methods: A cohort of nine patients with plantar fasciopathy was identified from a large observational repository for this study. Patient improvement after one application of WJ tissue allograft was assessed over 90 days using the Numeric Pain Rating Scale (NPRS), the Western Ontario and McMaster University Arthritis Index (WOMAC), and the Quality of Life Scale (QOLS). No adverse effects were reported. Results: Average scores and percent improvement were calculated from the initial application date to the final follow-up. All patients reported improvement in all scales utilized, with the most substantial improvements noted in WOMAC scores. Discussion: Although only a small cohort was observed, the positive results align with current literature that confirms the homologous nature of WJ and other connective tissues, providing a promising option for use in structural defects around the body. Conclusion: Future research is essential to establish Wharton’s jelly as a primary conservative care method in patients suffering from plantar fasciopathy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.109
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.121
GPT teacher head0.394
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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