Synthesis and Structural Characterization of a Glycoconjugated Re(CO)<sub>3</sub><sup>+</sup> Complex and Its Tendency for CO Release
Bibliographic record
Abstract
Rhenium(I) tricarbonyl complexes have been extensively studied for their potential in biomedical applications, e.g., photoactivated chemotherapy, while glycoconjugated metal complexes gain increasing attention for development of therapeutics and imaging agents due to their water solubility and biocompatibility. To combine these favorable properties, we synthesized a water-soluble compound, fac -[Re(CO) 3 (GluP)Cl], where the GluP is a diimine ( N,N ′) d -glucosamine Schiff base. Prior to exploring potential anticancer activities of this complex, we investigated its structure and stability in solutions using electro-spray ionization mass spectrometry (ESI-MS), NMR and other spectroscopic techniques. We found that the complex is relatively stable in water, keeping the GluP ligand intact and coordinated to the Re(I) ion, while the Re–Cl bond gradually hydrolyzes. The complex has two diastereomers due to the chirality of the Re(I) center. In each diastereomer the sugar C 1 –OH can exist as β-(major) or α-(minor) anomer. An ESI-MS study detected the formation of the dicarbonyl ion [Re(CO) 2 (GluP)] + in protic solvents, with the associated peak gaining intensity over time. This phenomenon was attributed to the gradual loss of a CO ligand under ambient conditions as confirmed by gas chromatography. This is the first report on a solvent-assisted CO release from a Re(CO) 3 + species without using ultraviolet (UV)-light.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".