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Reporting Guideline for Chatbot Health Advice Studies

2025· article· en· W4412822443 on OpenAlexaff
Bright Huo, Gary S. Collins, David Chartash, Arun James Thirunavukarasu, Annette Flanagin, Alfonso Iorio, Giovanni Cacciamani, Xi Chen, Nan Liu, Piyush Mathur, An‐Wen Chan, Christine Lainé, Daniela Pacella, Michael Berkwits, Stavros A. Antoniou, Jennifer Camaradou, Carolyn Canfield, Michael Mittelman, Timothy Feeney, Elizabeth Loder, Riaz Agha, Ashirbani Saha, Julio Mayol, Anthony Paulo Sunjaya, Hugh Harvey, Jeremy Y. Ng, Tyler McKechnie, Yung Lee, Nipun Verma, Gregor Štiglic, Melissa D. McCradden, Karim Ramji, Vanessa Boudreau, Monica Ortenzi, Joerg J Meerpohl, Per Olav Vandvik, Thomas Agoritsas, Helen Frankish, Michael C. Anderson, Xiaomei Yao, Stacy Loeb, Cynthia Lokker, Xiaoxuan Liu, Eliseo Güallar, Gordon Guyatt

Bibliographic record

VenueJAMA Network Open · 2025
Typearticle
Languageen
FieldPsychology
TopicDigital Mental Health Interventions
Canadian institutionsOttawa HospitalUniversity of British ColumbiaMcMaster UniversityWomen's College HospitalHamilton Health SciencesUniversity of Toronto
Fundersnot available
KeywordsChecklistComputer scienceGuidelineInterpretabilityData scienceMedicinePsychologyArtificial intelligence

Abstract

fetched live from OpenAlex

Importance: The rise in chatbot health advice (CHA) studies is accompanied by heterogeneity in reporting standards, impacting their interpretability. Objective: To provide reporting recommendations for studies evaluating the performance of generative artificial intelligence (AI)-driven chatbots when summarizing clinical evidence and providing health advice. Design, Setting, and Participants: CHART was developed in several phases after performing a comprehensive systematic review to identify variation in the conduct, reporting, and methodology in CHA studies. Findings from the review were used to develop a draft checklist that was revised through an international, multidisciplinary modified asynchronous Delphi consensus process of 531 stakeholders, 3 synchronous panel consensus meetings of 48 stakeholders, and subsequent pilot testing of the checklist. Results: CHART includes 12 items and 39 subitems to promote transparent and comprehensive reporting of CHA studies. These include title (subitem 1a), abstract or summary (subitem 1b), background (subitems 2ab), model identifiers (subitem 3ab), model details (subitems 4abc), prompt engineering (subitems 5ab), query strategy (subitems 6abcd), performance evaluation (subitems 7ab), sample size (subitem 8), data analysis (subitem 9a), results (subitems 10abc), discussion (subitems 11abc), disclosures (subitem 12a), funding (subitem 12b), ethics (subitem 12c), protocol (subitem 12d), and data availability (subitem 12e). Conclusions and Relevance: The CHART checklist and corresponding methodological diagram were designed to support key stakeholders including clinicians, researchers, editors, peer reviewers, and readers in reporting, understanding, and interpreting the findings of CHA studies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Direct model labels (unvalidated)

Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.

Model armCategoriesStudy designConfidence
gemmaMetaresearch
Domain: Reporting · Genre: Methods
About the Canadian research system: no · About a Canadian topic: no
Not applicablehigh
gptMetaresearch
Domain: Reporting · Genre: Methods
About the Canadian research system: no · About a Canadian topic: no
Not applicablehigh
models agreeAgreement compares identical category sets and study designs across arms.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.468
Threshold uncertainty score0.582

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0060.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.174
GPT teacher head0.559
Teacher spread0.385 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Labeled directly by 2 models reading the full record.

Study designNot applicable
DomainReporting
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations21
Published2025
Admission routes1
Has abstractyes

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