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Record W4412928967 · doi:10.1016/j.immuni.2025.07.011

From complexity to consensus: A roadmap for neutrophil classification

2025· review· en· W4412928967 on OpenAlexafffund
Lai Guan Ng, Iván Ballesteros, Marco A. Cassatella, Mikala Egeblad, Zvi G. Fridlender, Dmitry I. Gabrilovich, Qiang Gao, Zvi Granot, Ricardo Grieshaber‐Bouyer, H. Leighton Grimes, Catherine C. Hedrick, Andrés Hidalgo, Mariana J. Kaplan, Paul Kubes, Guang Sheng Ling, Liming Lu, Hongbo R. Luo, Tanya N. Mayadas, Niki M. Moutsopoulos, Melissa Ng, Peter A. Nigrović, Renato Ostuni, Mikaël J. Pittet, Daniela F. Quail, Carlos Silvestre-Roig, Oliver Soehnlein, Irina A. Udalova, Ruidong Xue, Ning Zhang, Immanuel Kwok

Bibliographic record

VenueImmunity · 2025
Typereview
Languageen
FieldImmunology and Microbiology
TopicNeutrophil, Myeloperoxidase and Oxidative Mechanisms
Canadian institutionsMcGill UniversityMcGill University Health CentreUniversity of Calgary
FundersNational Institute of Allergy and Infectious DiseasesNational Cancer InstituteNational Key Research and Development Program of ChinaNational Medical Research CouncilInterdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum WürzburgNatural Science Foundation of Beijing MunicipalityMinistero della SaluteLudwig Institute for Cancer ResearchIsrael Science FoundationElse Kröner-Fresenius-StiftungEuropean Research CouncilMinistry of Health -SingaporeFondazione TelethonFondation ISRECMinistry of Science and Technology of the People's Republic of ChinaDeutsche ForschungsgemeinschaftRheumatology Research FoundationPeabody FoundationCancer Research SocietyPfizerNational Natural Science Foundation of ChinaCanadian Institutes of Health ResearchAssociazione Italiana per la Ricerca sul CancroNational Institute of Arthritis and Musculoskeletal and Skin DiseasesLupus Research AllianceBeijing Nova ProgramNational Institutes of HealthU.S. Department of Health and Human Services
KeywordsBiologyComputational biologyImmunology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.005
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.005
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0030.003
Science and technology studies0.0010.002
Scholarly communication0.0040.006
Open science0.0020.002
Research integrity0.0030.006
Insufficient payload (model declined to judge)0.0050.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.146
GPT teacher head0.375
Teacher spread0.230 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations31
Published2025
Admission routes2
Has abstractno

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