Alkaloids of Delphinium Species Distributed in Georgia and Their Cytotoxic Activity
Bibliographic record
Abstract
The aim of the study was investigation the above and underground organs of Delphinium species distributed in Georgia: Delphinium speciosum Seed., Delphinium flexuosum Bieb., Delphinium freynii Conrath., Delphinium Shmalhausenii Abov., Delphinium elisabethaei N.Busch. for the content of alkaloids and to evaluate their cytotoxic activity. Of as a result phytochemical studies was conducted, in the total purified alkaloids obtained from the above-mentioned Delphinium plant species by liquid-liquid extraction method dominate diterpene alkaloids: methyllycaconitine and lycoctonin. Evaluation in vitro cytotoxic activity by Resazurin and Hoechst methods, in the case of the sum of alkaloids from above-ground organs of Delphinium Shmalhausenii Abov. revealed significant cytotoxic activity against A-549 (human lung carcinoma) and DLD-1 (rectal adenocarcinoma) cell culture lines with weak toxicity toward WS-1 (normal skin fibroblast) cells ; Alkaloids from underground organs of Delphinium Shmalhausenii Abov. and Delphinium freynii Conrath. Exhibited a moderate cytotoxicity; Weak expressed cytotoxic activity against A-549 cell lines was detected in the case of Delphinium elisabethaei N.Busch. alkaloids.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".