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Record W4413040937 · doi:10.2340/aos.v84.44126

Feasibility, acceptability and efficacy of non-invasive application of chlorhexidine dental coating for seniors in the community: a randomized controlled study

2025· article· en· W4413040937 on OpenAlexaffabout
Heidi Sveistrup, Irene Elizabeth DeHaan, Andrea Pepe, Howard C. Tenenbaum, Anton Svendrovski, Brenda Turgeon, Ross Perry

Bibliographic record

VenueActa Odontologica Scandinavica · 2025
Typearticle
Languageen
FieldDentistry
TopicOral microbiology and periodontitis research
Canadian institutionsUniversity of TorontoBruyèreUniversity of Ottawa
Fundersnot available
KeywordsMedicineChlorhexidineBleeding on probingPlaceboDentistryRandomized controlled trialOral hygieneChlorhexidine gluconateOral healthPeriodontal diseaseInternal medicineAlternative medicine

Abstract

fetched live from OpenAlex

Background: Poor oral health (caries and periodontal disease) in seniors is a health risk with minimal preventive care approaches evaluated. The objectives of this study were to: i) document the oral health status of a sample of Canadian seniors; and then ii) evaluate feasibility, acceptability and efficacy of non-invasive application of chlorhexidine for preventive oral health in the community. Methods: Dental examinations of 105 Ottawa seniors were followed by a randomized controlled study of 55 seniors with ³ 16 natural teeth and ³ 12 sites of bleeding on probing (BOP). Four treatments of either a chlorhexidine 10% w/v (active) or purified water (placebo) were applied over a 9-week period. Study sites included a hospital, seniors’ community centre, medical practice and long-term care facility. Treatments were applied by a hygienist or a nurse in 10-15 minutes, without dental cleaning or scaling. The primary endpoint was change in oral inflammation (BOP). Results: The sample had more decayed, missing or filled teeth (DMFT) and more periodontal disease than reported in the 2007-2009 Canada Health Measures Survey. BOP was reduced almost 2-fold more in the active group compared to placebo although significant in both groups (active: 7.91%, p<0.001; placebo: 4.1%, p=.018). The difference between groups in reducton of BOP failed to reach significance (p = 0.06) likely due to early stoppage of recruitment. Conclusion: A four-dose application of chlorhexidine significantly decreased oral inflammation as measured by BOP. The program of non-invasive preventive care in community settings is feasible, clinically impactful, and well received.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.005
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.110
Threshold uncertainty score0.594

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0060.005
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.367
Teacher spread0.338 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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