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Record W4413050314 · doi:10.1177/17407745251361741

Training the next generation of clinical trial biostatisticians

2025· article· en· W4413050314 on OpenAlexafffundabout
Sameer Parpia, Jacquelyn Dobinson, Anna Heath, Hubert Wong, Kevin E. Thorpe, Tolulope T. Sajobi, Shirin Golchi, Lawrence Mbuagbaw, Shun Fu Lee, Thi Thao Nguyen Ho, Valerie Bishop

Bibliographic record

VenueClinical Trials · 2025
Typearticle
Languageen
FieldDecision Sciences
TopicMeta-analysis and systematic reviews
Canadian institutionsPopulation Health Research InstituteMcGill UniversityUniversity of CalgaryInstitute for Clinical Evaluative SciencesUniversity of TorontoSickKids FoundationUniversity of British ColumbiaHospital for Sick ChildrenPublic Health OntarioMcMaster University
FundersClinical Trials Fund, Canadian Institutes of Health Research
KeywordsClinical trialMentorshipMedical educationBiostatisticsCurriculumMedicineProfessional developmentMedical physicsPsychologyNursingPublic healthPedagogy

Abstract

fetched live from OpenAlex

BackgroundThere is a critical shortage of biostatistics expertise and targeted training programs in clinical trials across Canada.MethodsThe Canadian Network for Statistical Training in Trials (CANSTAT), a pan-Canadian, multi-institutional training platform for biostatisticians in clinical trials, was developed to increase clinical trial biostatistics capacity in Canada.ResultsCANSTAT's training program integrates experiential learning through mentorship and placements at clinical trial sites, online workshops, and capacity-building meetings. The curriculum is designed to equip fellows with essential knowledge of clinical trials, technical skills, and practical experience necessary for their growth into professional trial biostatisticians, with several specific and measurable objectives set to achieve this goal. Educational materials, including CANSTAT competencies, reflective exercises, and individual development plans, are provided to monitor progress and ensure that fellows are meeting their academic and professional goals. Currently, CANSTAT has enrolled 19 fellows.ConclusionCANSTAT has developed a training program that equips fellows with essential skills in clinical trial design, conduct and analysis, and interprofessional communication, preparing them to effectively lead biostatistical efforts in clinical trials. By training a new generation of clinical trial biostatisticians, CANSTAT is strengthening Canada's clinical trial enterprise and improving health outcomes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.129
metaresearch head score (Gemma)0.177
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Incentives · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.871
Threshold uncertainty score0.681

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1290.177
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.002
Science and technology studies0.0040.004
Scholarly communication0.0070.003
Open science0.0050.008
Research integrity0.0030.006
Insufficient payload (model declined to judge)0.0150.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.994
GPT teacher head0.775
Teacher spread0.219 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainIncentives
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2025
Admission routes3
Has abstractyes

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