The pre-mRNA splicing factor ZOP1 contributes to the regulation of plant immunity
Bibliographic record
Abstract
The Arabidopsis (Arabidopsis thaliana) receptor-like protein SUPPRESSOR OF NPR1-1, CONSTITUTIVE 2 (SNC2) confers basal resistance against pathogens. The transcription factor CALMODULIN-BINDING PROTEIN 60 g (CBP60g) and its homolog SYSTEMIC ACQUIRED RESISTANCE DEFICIENT 1 (SARD1) define two parallel pathways downstream of SNC2. Here, we report the identification and characterization of ZINC-FINGER AND OCRE DOMAIN-CONTAINING PROTEIN 1 (ZOP1), a pre-mRNA splicing factor that functions as a positive regulator of SNC2-mediated immunity. ZOP1 functions immediately downstream of SNC2 before the defense signals branch to CBP60g and SARD1. Loss-of-function mutation in ZOP1 suppresses snc2-1D-mediated autoimmunity, while zop1 single mutants exhibit compromised resistance against pathogens. RNA-sequencing analysis revealed that many defense response genes are differentially expressed or have altered splicing patterns in the zop1 mutant. The genes downregulated in the zop1 mutant include BDA1 and RLP23, which encode two key regulators of plant defense. Overall, our study suggests that ZOP1 contributes to the regulation of plant immunity.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".