Bioenergetics and metabolism of the pulmonary endothelium. Scientific session I: ReSPIRE 2025
Bibliographic record
Abstract
Session I of the inaugural biennial Research Symposium on Pulmonary Injury and Repair of the Endothelium (ReSPIRE) highlighted recent advances in endothelial bioenergetics and metabolism and their role in pulmonary vascular diseases. Emerging evidence suggests that the maladaptation of metabolic pathways in the lung endothelium contributes to the progression of the acute respiratory distress syndrome (ARDS) and pulmonary arterial hypertension (PAH). The conference highlighted several new aspects of endothelial metabolism, including the use of alternative fuel sources such as fructose and fatty acids, inflammatory signaling mediated by mitochondrial depolarization, bioenergetic reprogramming through isoform switching of genes during hypoxia, and feedback regulation of metabolism by hypercapnia. Ultimately, these findings point to future research directions aimed at identifying mechanisms of dysregulated endothelial metabolism, which could serve as therapeutic targets for pulmonary vascular diseases.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.010 | 0.007 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".