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Record W4413115603 · doi:10.1371/journal.pone.0330129

Upper limb muscle reflexes in real and virtual environments: Insights into sensorimotor adaptations

2025· article· en· W4413115603 on OpenAlexafffund
Daniel D. Hodgson, Brian H. Dalton, Tyler Cluff, Ryan M. Peters

Bibliographic record

VenuePLoS ONE · 2025
Typearticle
Languageen
FieldComputer Science
TopicVirtual Reality Applications and Impacts
Canadian institutionsHotchkiss Brain InstituteOkanagan University CollegeUniversity of British Columbia, Okanagan CampusUniversity of British ColumbiaUniversity of Calgary
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsReflexPhysical medicine and rehabilitationNeuroscienceAnatomyBiologyMedicine

Abstract

fetched live from OpenAlex

INTRODUCTION: The mechanisms influencing neuromuscular adaptations in the upper limb within dynamic environments remain understudied, especially when exposed to altered visual and emotional conditions such as those simulated in virtual reality (VR). Here we utilize VR to manipulate visual feedback, inducing motion sickness and modulating sympathetic arousal, while assessing adaptations in sensorimotor integration in the upper extremity using electrically evoked and muscle stretch reflexes. METHODS: Eighteen healthy young adults experienced four experimental conditions while sustaining submaximal activation of their flexor carpi radialis (FCR) muscle by isometrically supporting a weighted load: baseline real-world (Pre-VR), stationary VR (VR-BL), dynamic VR with motion perception via a virtual rollercoaster ride (VR-C), and post-VR following re-entry to the real environment (Post-VR). Muscle activity was monitored via electromyography (EMG), while reflex activity was assessed using electrical (H-reflexes) and mechanically induced (noisy tendon vibration; NTV) reflexes in the FCR. Additionally, electrodermal activity (EDA) and psychosocial indicators of motion sickness (subjective questionnaires) were measured throughout. RESULTS: H-reflex amplitude was suppressed during VR-C, which persisted into Post-VR; whereas NTV-reflexes were unaffected across conditions. Sympathetic arousal (e.g., EDA) and motion sickness symptoms increased significantly during VR-C compared to Pre-VR, but rapidly returned to baseline Post-VR. EMG within the target muscle (FCR) as well as in the brachioradialis was maintained across conditions, though increased activation was observed in the biceps brachii beginning at the onset of VR immersion (VR-BL). DISCUSSION: These findings suggest suppression of spinal excitability (H-reflex) when the perception of motion (VR-C) was added to a stationary VR experience. Meanwhile, muscle spindle sensitivity (NTV-reflex) remained consistent, highlighting potential fusimotor adaptations to maintain sensorimotor function under altered visual and emotional states. Persistent H-reflex suppression post-VR indicates lingering neuromuscular effects of immersive VR, underscoring the need for further exploration of VR's implications for rehabilitation and virtual training environments.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.839
Threshold uncertainty score0.371

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.037
GPT teacher head0.263
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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