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Record W4413129745 · doi:10.1111/acel.70191

Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans

2025· article· en· W4413129745 on OpenAlexafffund
Vincent Marcangeli, Marina Cefis, Rami Hammad, Jordan Granet, Jean‐Philippe Leduc‐Gaudet, Pierrette Gaudreau, Mylène Aubertin‐Leheudre, Marc Bélanger, Richard Robitaille, José A. Morais, Gilles Gouspillou

Bibliographic record

VenueAging Cell · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAldose Reductase and Taurine
Canadian institutionsMcGill University Health CentreCentre for Interdisciplinary Research in RehabilitationUniversité de MontréalMcGill UniversityChristie (Canada)Centre Hospitalier de l’Université de MontréalUniversité du Québec à Trois-RivièresQuebec Rehabilitation Research NetworkUniversité du Québec à MontréalGroup for Research in Decision AnalysisInstitut Universitaire de Gériatrie de Montréal
FundersFonds de Recherche du Québec - SantéNatural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health Research
KeywordsTaurineBiologyHealthy agingEndocrinologyInternal medicineGerontologyBiochemistryMedicineAmino acid

Abstract

fetched live from OpenAlex

Taurine deficiency was recently proposed as a driver of aging in various species, including humans. To test this hypothesis, we assessed whether circulating taurine was associated with aging and physical performance in 137 physically inactive and physically active men aged 20-93. No association between circulating taurine levels and age, muscle mass, strength, physical performance, or mitochondrial function was observed, thereby challenging the implication of taurine deficiency as a primary driver of aging in humans.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.016
Threshold uncertainty score0.417

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.283
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes2
Has abstractyes

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