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Record W4413139183 · doi:10.1152/ajprenal.00158.2025

Impaired vascular function in patients with chronic kidney disease who have elevated symmetric dimethylarginine but not asymmetric dimethylarginine

2025· article· en· W4413139183 on OpenAlexaff
Ann‐Katrin Grotle, Jasdeep Kaur, Rachel J. Skow, Taha Alhalimi, Benjamin E. Young, Damsara Nandadeva, Brandi Y. Stephens, P.F. Mohan, Paul J. Fadel

Bibliographic record

VenueAmerican Journal of Physiology-Renal Physiology · 2025
Typearticle
Languageen
FieldMedicine
TopicNitric Oxide and Endothelin Effects
Canadian institutionsUniversity of Alberta
FundersNational Heart, Lung, and Blood Institute
KeywordsAsymmetric dimethylarginineMedicineInternal medicinePulse wave velocityKidney diseaseRenal functionCardiologyEndocrinologyReactive hyperemiaBlood pressureBlood flowArginineChemistry

Abstract

fetched live from OpenAlex

The associations between symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) and measures of vascular function were investigated in patients with stage 3-4 chronic kidney disease (CKD). We found that SDMA exhibited stronger relationships with vascular function than ADMA. However, the strength of associations was modest, potentially limiting their role as standalone predictors of vascular dysfunction. Nonetheless, these data support emerging evidence of a differential impact of SDMA and ADMA in patients with CKD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.002

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.232
Teacher spread0.227 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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