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Record W4413304710 · doi:10.1088/1361-6560/adfcae

Theoretical optimal <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mrow> <mml:mstyle/> </mml:mrow> <mml:mrow> <mml:mn>232</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> Th target thicknesses for <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mrow> <mml:mstyle/> </mml:mrow> <mml:mrow> <mml:mn>225</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> Ac production at proton energies of 70–200 MeV

2025· article· lv· W4413304710 on OpenAlexaff
J. S. Jang, Paul Schaffer, Valery Radchenko, Louis Moskven, Nobuyoshi Akimitsu, Youichiro Wada, Cornelia Hoehr

Bibliographic record

VenuePhysics in Medicine and Biology · 2025
Typearticle
Languagelv
FieldMedicine
TopicRadiopharmaceutical Chemistry and Applications
Canadian institutionsUniversity of VictoriaSimon Fraser UniversityUniversity of British ColumbiaTRIUMF
FundersJapan Society for the Promotion of Science
KeywordsPhysicsProtonNuclear physicsProduction (economics)Atomic physicsNuclear reaction

Abstract

fetched live from OpenAlex

Abstract Objective. Conventional 232 Th target thicknesses used for 225 Ac production are substantially smaller than the proton ranges, underutilizing the 225 Ac production potential of proton beams. This study explores theoretical optimal thicknesses of 232 Th targets at widely used proton energies, 70–200 MeV. Approach. Yields of 225 Ac and impurity levels of 227 Ac were calculated for proton energies of 70–200 MeV and 232 Th target thicknesses of 0.05–24 mm using Monte Carlo simulations. Ranges of optimal target thicknesses were defined for each proton energy based on the relative rates of change (RROCs) of 225 Ac yields per target thickness of 0.25 mm and on energy-adjusted RROC thresholds. Expected 225 Ac yield gains from using the optimal thicknesses were also estimated. Main results. The ranges of theoretical optimal thicknesses for representative energies, 70, 100, 160, and 200 MeV, were found to be 2–2.25 mm, 4.5–6.25 mm, 7.75–14.5 mm, and 14.25–21.75 mm, respectively. All these thicknesses are markedly larger than those of the conventional thin targets used for medium- to large-scale 225 Ac production, 0.25 mm and 0.5 mm. By using these optimal target thicknesses, 225 Ac yields are expected to increase by factors of up to 8.8 at 70 MeV and 63.8 at 200 MeV. Actinium-227 impurity levels were unaffected by target thickness optimization at all proton energies. Significance. Optimizing 232 Th target thicknesses can provide proton accelerator facilities operating in the 70–200 MeV range with a straightforward means of increasing their

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.061
Threshold uncertainty score0.205

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0610.011

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.038
GPT teacher head0.304
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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