Motor cortical excitability and inhibition are differentially modulated by aerobic exercise intensity
Bibliographic record
Abstract
Acute aerobic exercise (AEX) enhances motor learning and promotes neuroplasticity. Although previous studies examined the impact of AEX on primary motor cortex (M1) excitability, the dose-response relationship across a broad intensity spectrum with consistent exercise parameters remains to be fully elucidated. This study investigated the impact of AEX intensity on distinct M1 circuits using transcranial magnetic stimulation (TMS). Thirty right-handed adults underwent four experimental sessions: 20-min rest (control), light (LIIT: 35% heart rate reserve [HRR]), moderate (MIIT; 55% HRR), and high-intensity interval training (HIIT; 80% HRR) AEX. The interval cycling sessions alternated between 3 min at the target intensity and 2 min of active recovery (25% HRR). We performed TMS measures before (Pre), immediately post (Post0), and 20-min post (Post20) AEX/rest to assess corticospinal excitability and short-interval intracortical inhibition (SICI). We found that: (i) HIIT and MIIT increased corticospinal excitability, with HIIT eliciting a sustained increase, and (ii) all AEX intensities (LIIT, MIIT, HIIT) decreased SICI, with the greatest sustained reduction following MIIT. Altogether, our results demonstrate the impact of HIIT and MIIT to enhance corticospinal excitability and reduce SICI in M1. This study provides evidence for a dose-response effect of AEX intensity on the modulation of distinct M1 circuits.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".