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Record W4413359295 · doi:10.1101/2025.08.16.670672

Transgenic Cowpea Expressing Synthetic <i>Bt</i> Cry1Ab Confers High Resistance to Legume Pod Borer ( <i>Maruca vitrata</i> )

2025· preprint· en· W4413359295 on OpenAlexaff
Muthuvel Jothi, Sanjeev Kumar, Devendra Kumar Maravi, Illimar Altosaar, Vinay Kalia, Lingaraj Sahoo

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldAgricultural and Biological Sciences
TopicAgricultural pest management studies
Canadian institutionsUniversity of Ottawa
Fundersnot available
KeywordsPoint of deliveryBiologyTransgeneResistance (ecology)LegumeGenetically modified cropsAgronomyBiotechnologyGeneGenetics

Abstract

fetched live from OpenAlex

Abstract Cowpea, an important food legume crop, suffers significant yield losses due to insect pests, particularly the legume pod borer ( Maruca vitrata ). Narrow genetic base and lack of sufficient resistance to M. vitrata in existing cowpea germplasm, make them less effective in managing M. vitrata populations. To address this challenge, a transgenic approach is explored. In this study, we develop transgenic cowpea with enhanced resistance to M. vitrata by overexpressing a synthetic cry1Ab gene, driven by constitutive CaMV35S viral promoter, in an Indian cowpea cultivar. High expression of Cry1Ab was detected in leaves and pods. Bioassays with M. vitrata and Helicoverpa armigera larvae demonstrated significant resistance of transgenic lines to these lepidopteran pests. The transgenic lines exhibited reduced pod damage, decreased larval feeding, and increased insect mortality compared to non-transgenic controls. NMR analysis demonstrated absence of any new metabolites in transgenic plants. Furthermore, these transgenic lines showed no penalty on growth and development. The transgenic lines exhibited no observable phenotypic drawbacks, indicating their promise for sustainable agricultural practices. Our findings suggest that these transgenic cowpea lines could offer broad-spectrum protection against these pests, providing an effective pest management solution.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.653
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0020.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.196
Teacher spread0.184 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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