CDK5-mediated hyperphosphorylation of Tau217 impairs neuronal synaptic structure and exacerbates cognitive impairment in Alzheimer’s disease
Bibliographic record
Abstract
Numerous studies have demonstrated that tau phosphorylated at threonine 217 (p-T217) in cerebrospinal fluid (CSF) or plasma is a potential biomarker for Alzheimer's disease (AD). However, the detailed pathological effects of elevated p-T217 and the mechanisms underlying T217 phosphorylation remain incompletely understood. In this study, we revealed a role of tau phosphorylated at T217 in AD. In 5 × FAD mice, increased p-T217 levels, correlated with CDK5 activation, were associated with neurite damage and neuronal apoptosis. Mice expressing a phospho-mimetic T217E mutant in the hippocampus exhibited significant learning impairments in the Morris water maze and Y-Maze test, along with reduced levels of the synaptic proteins Drebrin and PSD95. Electron microscopy revealed severe synaptic and microtubules damage in these mice, along with disrupted axonal structures confirmed by Golgi staining. Additionally, hyperactivation of CDK5 through p25 overexpression increased T217 phosphorylation, whereas CDK5 inactivation reduced it. The study concludes that CDK5 mediated Tau phosphorylation at T217 contributes to synaptic damage and cognitive deficits, highlighting it as a potential therapeutic target for AD.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".