Life Expectancy of Renal Cell Carcinoma with Variant Histology
Bibliographic record
Abstract
BACKGROUND AND OBJECTIVE: The effect of variant histology in renal cell carcinoma (vhRCC) on survival relative to age- and sex-matched population-based controls is unknown. This study aims to analyze the life expectancy of vhRCC patients. METHODS: In the Surveillance, Epidemiology and End Results (SEER) database (2004-2016), we identified 2928 patients with vhRCC, including mesenchymal, collecting duct, medullary, mucinous, and neuroendocrine RCC, as well as RCC of sarcomatoid and rhabdoid differentiation. Kaplan-Meier plots addressed overall survival relative to simulated life expectancy in population-based controls (Monte Carlo simulation), were derived from the Social Security Administration life tables. KEY FINDINGS AND LIMITATIONS: Of the 2928 vhRCC patients, 1905 (65%) harbored sarcomatoid, 404 (14%) mesenchymal, 318 (11%) collecting duct, 94 (3%) rhabdoid, 80 (3%) medullary, 68 (2%) mucinous, and 59 (2%) neuroendocrine RCC. Most vhRCC subtypes exhibit regional or metastatic stage at diagnosis, except for mucinous RCC. When diagnosed in metastatic stage, all vhRCC subtypes exhibited a decrease in survival rate ranging from -75% to -98% between controls and cases, except for mucinous and neuroendocrine RCC, with the least decrease in survival rate of -62% and -59%, respectively. In regional stage, all vhRCC subtypes exhibited a decrease in survival rate ranging from -68% to -41% between controls and cases, except for neuroendocrine RCC, with the least decrease in survival rate of -27%. Finally, in localized stage, all vhRCC subtypes exhibited a decrease in survival rate ranging from -56% to -22% between controls and cases, except for rhabdoid and mucinous RCC, with the least decrease in survival rate of -11% and -6%, respectively. CONCLUSIONS AND CLINICAL IMPLICATIONS: Most vhRCC subtypes reduce survival drastically relative to life expectancy of population-based controls, except for localized rhabdoid and mucinous RCC. Especially, medullary RCC leads to distinct reductions in life expectancy, irrespective of the stage at presentation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".