A retrospective comparison of the efficacy of sennoside A + B calcium solutions and polyethylene glycol solutions for bowel preparation prior colonoscopy
Bibliographic record
Abstract
Background and Aim: Colonoscopy is a widely used method for diagnosing colorectal diseases. Its diagnostic accuracy largely depends on the quality of bowel preparation. Two commonly used bowel cleansing agents are sennoside A + B calcium and polyethylene glycol solutions. This study aims to compare the effectiveness of these two agents using different bowel preparation scoring systems. Materials and Method: Colonoscopies performed by a single endoscopist at a tertiary center between February 2024 and April 2025 were retrospectively evaluated. Patients received either polyethylene glycol or sennoside A + B calcium solutions for bowel preparation, based on informed patient preference. Bowel cleansing quality was assessed segmentally using the Boston bowel preparation scale, the Ottawa bowel preparation scale, and the Chicago bowel preparation scale. Results: A total of 114 patients were included in the study. The polyethylene glycol group (n = 53) achieved significantly higher scores on the Boston bowel preparation scale and the Chicago bowel preparation scale, and lower (better) scores on the Ottawa bowel preparation scale, indicating superior bowel cleansing quality compared to the sennoside group (n = 61). A strong negative correlation was observed between the Boston and Ottawa bowel preparation scales, while a strong positive correlation was found between the Boston and Chicago bowel preparation scales. The Ottawa and Chicago bowel preparation scales also demonstrated a strong negative correlation. No statistically significant correlations were found between the number of previous colonoscopies or the time since the last procedure and any of the three bowel preparation scales. Conclusion: This study demonstrated that polyethylene glycol solutions provide significantly better bowel cleansing quality compared to sennoside A + B calcium, as evaluated using three strongly correlated bowel preparation scales. The findings suggest that lower body mass index and previous colonoscopy experience may be associated with improved bowel preparation, possibly due to better patient adherence. While both agents are commonly used in clinical practice, polyethylene glycol solutions may be the preferred option, especially in patients who have undergone prior colonoscopy with inadequate bowel cleansing.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".