Comparison of the Efficacy Between the Combination of Herbal Extracts and Silicone Derivative VS the Combination of Herbal Extracts, Silicone Derivative and Sunscreen in Reducing Scar Development at Donor Site of the Split Thickness Skin Graft
Bibliographic record
Abstract
Background: To compare the efficacy between the combination of herbal extracts and silicone derivative VS the combination of herbal extracts, silicone derivative and sunscreen in reducing scar development at the split-thickness skin graft donor site and also the different between the two treatment groups and placebo. Methods: A prospective randomized double-blind control study to compare efficacy between the combination of herbal extracts and silicone derivative (Group I) VS the combination of herbal extracts, silicone derivative and sunscreen (Group II) VS placebo (Group III) in reducing scar development at the split-thickness skin graft donor site within 1 month after complete epithelialization. Scar assessments using the Vancouver Scar Scale (VSS) and Cutometer® (The Multiprobe Adapter System Cutometer Dual MPA580) were taken 4, 8, 16 and 24 weeks postoperatively. Results: Of the 12 patients, 8 were enrolled, total 18 split-thickness skin graft donor sites were evaluated in this study. There was statistically significant lower in itching parameter of VSS between treatment groups compared to the placebo group after 8 weeks of treatment; Group I VS Group III (p = 0.003, 0.002, 0.002 at 8, 16, 24 weeks, respectively), Group II VS Group III (p = 0.003, 0.002, 0.002 at 8, 16, 24 weeks, respectively). After 24 weeks of treatment, there was statistically significant lower erythema index in Group II when compare to Group III (359.09 VS 378.40, p = 0.004). There was statistically significant lower melanin index in both treatment groups when comparerd to placebo group; Group I VS Group III (317.80 VS 341.600, p = 0.013)) and Group II VS Group III (316.19 VS 341.60, p = 0.028). There was no statistically significant different in pliability index between groups. Conclusion: The results from this study confirmed that the combination of herbal extracts and silicone derivative with or without sunscreen could reduce scar itching and these combinations might improve scar pigmentation and tend to reduce scar erythema.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".