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Record W4413426442 · doi:10.1002/gin2.70038

Protocol for the Creation of the Guidelines International Network–McMaster Guideline Development Checklist Extension for Integrating Artificial Intelligence in the Guideline Enterprise (Guidelines‐Artificial Intelligence Extension)

2025· article· en· W4413426442 on OpenAlexaff
Manuel Marques‐Cruz, Bernardo Sousa‐Pinto, Wojtek Wiercioch, Marge Reinap, Ignacio Neumann, Yuan Chi, Artur Nowak, Mariette Awad, Monika Nothacker, Jan Brożek, Pablo Alonso‐Coello, Amir Qaseem, Elie A. Akl, Holger J. Schünemann

Bibliographic record

VenueClinical and Public Health Guidelines · 2025
Typearticle
Languageen
FieldMedicine
TopicClinical practice guidelines implementation
Canadian institutionsMcMaster UniversityImpactCochrane
Fundersnot available
KeywordsGuidelineChecklistProtocol (science)Extension (predicate logic)Computer scienceArtificial intelligenceMedicinePsychologyPathology

Abstract

fetched live from OpenAlex

ABSTRACT Introduction Artificial intelligence (AI) has the potential to support processes of the guideline enterprise. To support the adequate preplanning and the transparent reporting of the use of AI in the guideline enterprise, the Guidelines International Network (GIN) proposed the development of an extension of the GIN–McMaster Guideline Development Checklist (GDC) for the use of AI in guidelines. Here we describe the protocol for the development of this extension. Methods We will follow a multiphase approach to generate an extension of the GIN–McMaster GDC. We will start by prompting a large language model to suggest relevant items for the extension. We will subsequently revise the obtained outputs in an iterative process involving the different elements of the working group. This iterative process will be informed by a scoping review. We will then reach different stakeholders to test the proposed checklist extension on their easiness of use, implementation, feasibility and reasonability. Questions This protocol lays the ground for the development of an extension to the GIN–McMaster GDC for the use of AI in guidelines. This extension will support the adequate use of AI in the guideline enterprise.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.042
metaresearch head score (Gemma)0.144
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesMetaresearch
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.833
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0420.144
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.549
GPT teacher head0.598
Teacher spread0.049 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designOther design
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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