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Record W4413446669 · doi:10.33425/2692-7918.1099

NEURON ON: A Bioactive Moringa Oil Targeting Oxidative Stress and Silent Synapses in Neurological Disorders Including Epilepsy

2025· article· en· W4413446669 on OpenAlexaff
L Cruz-Rodriguez, Anna Carrasco, Carmen Gallo García, A Angomas, Emili Martı́nez, M Valle-Orta, I Rosales-Castro, EA Dans

Bibliographic record

VenueNeurology and Neuroscience · 2025
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicMoringa oleifera research and applications
Canadian institutionsHotel Dieu Hospital
Fundersnot available
KeywordsEpilepsyOxidative stressNeuroscienceMoringaMedicinePsychologyTraditional medicineInternal medicine

Abstract

fetched live from OpenAlex

Recent research into neuronal regeneration for epilepsy has focused on silent, or passive, synapses— synaptic junctions that are anatomically present but electrically inactive. These synapses may serve as potential sites for reactivation and neuronal recovery, especially following injury or disease. "NEURON ON," a novel bioactive moringa oil formulation enriched with CBD and delivered via exogenous exosomes, aims to reduce oxidative stress and reawaken silent synapses. In a proof-of-concept trial, 243 patients with epilepsy (ages 25–75) received personalized sublingual doses of NEURON ON. The oxidative stress coefficient (OSC) was measured using the LONGLIFE OXY-LORD (LLOL) calculator. Results demonstrated that 198 participants (81.48%) showed a 50% reduction in OSC, corresponding to a 90% oxidative stress relief rate. Additionally, patients exhibited an average 12% reduction in estimated biological age. These findings suggest that NEURON ON may promote neuronal regeneration by forming a melanin-like lipid interface that facilitates connectivity among low-activity neurons. Given these outcomes, EEG evaluations are recommended to validate functional neural recovery. NEURON ON holds promise as a personalized oxidative stress-reducing therapy for epilepsy and other oxidative pathologies affecting neuronal connectivity.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.391
Threshold uncertainty score0.407

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.280
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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