Who truly benefits from gilteritinib combinations in FLT3-mutated relapsed-refractory(R/R) AML: a Canadian single center analysis
Bibliographic record
Abstract
Treatment of relapsed-refractory (R/R) FLT3 mut AML is an unmet need. Use of gilteritinib monotherapy in the ADMIRAL trial resulted in a modest prolongation of overall survival (OS) from 5.6 months to 9.3 months [ 1 ]. Following the results from in-vitro studies showing synergism between gilteritinib and venetoclax [ 2 , 3 ], this combination was studied in a phase Ib/II study, resulting in a median OS of 10.0 months [ 4 ]. The combination of gilteritinib with azacytidine-venetoclax in another phase I/II study resulted in a median OS of 5.8 months in the R/R cohort [ 5 ]. Thus, even though combination therapy shows improved response rates, cross trial comparisons show the survival with combination therapy to be similar to that of monotherapy at the cost of increased toxicities [ 1 , 4 , 5 ]. Thus, clinical equipoise persists regarding the optimal regimen for R/R FLT3 mutated AML. To address this knowledge gap, we conducted a single center retrospective study to evaluate our experience with use of gilteritinib-based therapy in the R/R FLT3 mut AML population. Specifically, we compared the outcomes of patients who received gilteritinib monotherapy with gilteritinib combination therapy.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.004 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.008 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".