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Record W4413760484 · doi:10.3389/fneur.2025.1602104

Thirty minutes of daily artificial gravity does not mitigate head down tilt induced brain activity changes during cognitive task performance

2025· article· en· W4413760484 on OpenAlexfundno aff
Grant D. Tays, Heather R. McGregor, Yiri E. De Dios, Edwin Mulder, Jacob J. Bloomberg, Ajitkumar P. Mulavara, Scott J. Wood, Rachael D. Seidler

Bibliographic record

VenueFrontiers in Neurology · 2025
Typearticle
Languageen
FieldMedicine
TopicSpaceflight effects on biology
Canadian institutionsnot available
FundersNatural Sciences and Engineering Research Council of CanadaNational Institutes of HealthNational Institute on AgingNuclear Safety and Security CommissionUniversity of FloridaNational Aeronautics and Space Administration
KeywordsTask (project management)Head-Down TiltHead tiltCognitionTilt (camera)Head (geology)NeurosciencePhysical medicine and rehabilitationPsychologyMedicineBiologySurgeryEngineeringCommunicationBed rest

Abstract

fetched live from OpenAlex

Introduction: Studies have shown that microgravity results in high dual task costs when crewmembers perform cognitive-motor dual tasking. Head-down tilt bedrest (HDBR) has been widely used as a spaceflight analog environment, recreating some of the sensorimotor and cognitive changes, headward fluid shifts, and unloading of bones and muscles. Here, we examined whether artificial gravity (AG) mitigates changes in cognitive performance and associated brain activity that occur in the HDBR environment. Methods: = 8 controls) during the course of 60 days HDBR. Participants performed spatial working memory and cognitive-motor dual tasking prior to entering HDBR, during HDBR and post-HDBR. Results: Brain activation patterns associated with these two tasks changed with HDBR, but there was no difference between the AG and control groups. Compensatory brain-behavioral change-change correlations were observed, where those who increased activation the most had the least decrease in motor tapping accuracy from pre-HDBR to late-HDBR. Discussion: These results suggest that AG does not reduce the need for compensatory brain responses that occur with HDBR, but longer duration and/or more optimal AG phasing may be required.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.146
Threshold uncertainty score0.951

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.270
Teacher spread0.256 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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