Quality Control of Raw Plant Materials and Stability Testing under Accelerated Storage Conditions of Kheaw-Hom Remedy Extract
Bibliographic record
Abstract
Introduction: Kheaw-Hom remedy (KH), a Thai traditional antipyretic medicine, is included in the National List of Essential Medicine. Currently, there is no scientific report on its standard requirements for quality control and stability testing. Objectives: To determine the quality control and stability testing of KH on anti-inflammatory activity and its bioactive markerMethods: Quality control methods (loss on drying, total ash, acid-insoluble ash, extractive values, and heavy metals) of KH and raw plant materials were performed according to Thai Herbal Pharmacopoeia (THP). The stability testing of the ethanolic extract of KH (KHE) was stored under 40 ± 2 ºC and 75 ± 5% relative humidity for 180 days. Anti-inflammatory activity on LPS-induced nitric oxide (NO) production in RAW264.7 macrophage cells were evaluated. Ethyl p-methoxycinnamate (EPMC), a bioactive marker, was analyzed using high performance liquid chromatography (HPLC).Results: KH showed loss on drying, total ash, acid-insoluble ash, ethanol soluble extractive and water-soluble extractive values of 8.66 ± 0.47%, 6.17 ± 0.06%, 1.14 ± 0.07%, 10.62 ± 0.12%, and 13.78 ± 0.54%, respectively. Eighteen plant materials met the requirements of THP. The anti-inflammatory activity on nitric oxide inhibition and EPMC content of KHE on day 180 exhibited no significant difference when compared with day 0.Conclusions: This study is the first report on quality control and stability testing of KH. All KH and its plant components conformed to the standard requirements of THP. KHE could be stored at room temperature for two years.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".