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Record W4413818601 · doi:10.58931/crt.2025.2265

What Can We Tell Our Patients About Rheumatoid Arthritis Risk?

2025· article· en· W4413818601 on OpenAlexaff
Liam J. O’Neil, Hani El‐Gabalawy

Bibliographic record

VenueCanadian rheumatology today. · 2025
Typearticle
Languageen
FieldMedicine
TopicRheumatoid Arthritis Research and Therapies
Canadian institutionsUniversity of Manitoba
Fundersnot available
KeywordsRheumatoid arthritisMedicineInternal medicineIntensive care medicine

Abstract

fetched live from OpenAlex

You are seeing a 45-year-old female with a chief complaint of joint pain in the hands and feet. The symptoms have been apparent for 6 months. There was no preceding illness. She reports morning stiffness of the affected joints. The patient denies any joint swelling. Her medical history is notable for a strong family history of Rheumatoid Arthritis, and she currently smokes one pack of cigarettes daily. On physical examination, the joints appear normal, with full range of motion and no obvious tenderness to palpation. There is no evidence of synovitis or rashes. Laboratory investigations show elevated anti-citrullinated protein antibody level of 135, and her rheumatoid factor level is 45. C-reactive protein is within normal limits. Radiographs of the hands and feet are normal. Questions: 1. What is her likelihood of developing rheumatoid arthritis within the next 3 years? 2. Are there any other tests you need to order? 3. Can rheumatoid arthritis be prevented in this individual? What advice can you provide her?

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.646
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.247
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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