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Record W4413843693 · doi:10.1111/cod.70013

Treatment Willingness and Importance of Skin Clearance for Patients With Chronic Hand Eczema

2025· article· en· W4413843693 on OpenAlex
Maria Oberländer Christensen, Lea K. Nymand, Caroline Meyer Olesen, Silvia Mariel Ferrucci, Christoph Schlapbach, Swen Malte John, Sonja Molin, Claus Zachariae, Simon Francis Thomsen, Jacob P. Thyssen, Alexander Egeberg

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueContact Dermatitis · 2025
Typearticle
Languageen
FieldMedicine
TopicContact Dermatitis and Allergies
Canadian institutionsQueen's University
Fundersnot available
KeywordsMedicineInterquartile rangeCohortDemographicsQuality of life (healthcare)Hand eczemaInternal medicineDermatologyAllergyContact dermatitisImmunologyDemography

Abstract

fetched live from OpenAlex

BACKGROUND: Chronic hand eczema (CHE) has a significant negative impact on quality of life and a high disease burden. OBJECTIVE: To investigate the importance of skin clearance and daily time trade off (dTTO) in adult patients with CHE. METHODS: Patients with CHE from the Danish Skin Cohort were sent a digital survey regarding demographics, lifestyle factors, CHE characteristics, importance of obtaining skin clearance, and dTTO. RESULTS: Of 372 patients with current CHE, 58.1%, 26.3%, 11.0%, and 4.6% reported having mild, moderate, severe, and very severe CHE, respectively. Patients reported a median of 9 (interquartile range: [5-10], 9 [7-10], 10 [8-10] and 10 [9-10]) when asked about the importance of obtaining 50%, 75%, 90%, and 100% skin clearance, respectively (numerical rating scale from 0 [lowest] to 10 [highest]). Importance of skin clearance increased with increasing CHE severity (p < 0.001). One in three patients (41.2%) with either severe or very severe CHE was willing to allocate > 1 h a day to treat their CHE. CONCLUSIONS: Skin clearance was important among CHE patients, and patients with more severe disease were willing to allocate a substantial amount of time every day to treat their CHE.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.064
Threshold uncertainty score0.506

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.237
Teacher spread0.232 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it