Improving adherence to physical activity in treatment-resistant depression: Protocol for a pilot randomized controlled trial of a remotely delivered program
Bibliographic record
Abstract
BACKGROUND: At least 30% of individuals with major depressive disorder do not respond to conventional treatments (i.e., they meet the criteria for treatment-resistant depression [TRD]). Alternative therapeutic modalities are needed. Some studies have reported that physical activity (PA) programs can improve depressed mood and reduce depressive symptoms. However, few studies to date have examined the effects of PA as an adjunct to standard treatment for TRD. The MoveU.HappyU PA program has been shown to improve depressive symptoms in university students. Before a definitive trial testing MoveU.HappyU in TRD can be designed, pilot data is needed. METHODS: The current study is a single-site, pilot, two-arm randomized controlled trial. It will investigate the feasibility of randomizing 30 adult participants with TRD to: (1) a remotely delivered four-week MoveU.HappyU adjunct to treatment as usual (TAU), or (2) TAU. Acceptability of the PA program will also be assessed. Participants randomized to the PA program will meet weekly with a program trainer to engage in PA counselling and structured PA. They will also be instructed to independently complete 120 minutes of PA per week. The four-week intervention period will be followed by six weeks of observation. Throughout the study, both groups will receive the same digital monitoring via self-report questionnaires and a wearable device, as well as traditional monitoring (i.e., clinical assessments administered by a masked rater). DISCUSSION: This pilot study will assess the feasibility of a trial implementing MoveU.HappyU for TRD and generate clinical parameter estimates for larger studies. This line of research highlights the importance of PA programs that integrate personalized PA with PA counselling. It will also influence the development of interventions that are more tailored and effective. TRIAL REGISTRATION: ClinicalTrials.gov NCT06404320.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.036 | 0.029 |
| Meta-epidemiology (narrow) | 0.006 | 0.004 |
| Meta-epidemiology (broad) | 0.011 | 0.006 |
| Bibliometrics | 0.003 | 0.004 |
| Science and technology studies | 0.005 | 0.004 |
| Scholarly communication | 0.004 | 0.003 |
| Open science | 0.005 | 0.002 |
| Research integrity | 0.008 | 0.010 |
| Insufficient payload (model declined to judge) | 0.071 | 0.010 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".